中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
4期
3-5
,共3页
门冬胰岛素30%甘精胰岛素%2型糖尿病
門鼕胰島素30%甘精胰島素%2型糖尿病
문동이도소30%감정이도소%2형당뇨병
Insulin aspart 30 injection%Insulin glargine injection%Type 2 diabetes
目的 观察每天注射一次门冬胰岛素30联合口服药对初诊2型糖尿病患者血糖控制及其对胰岛β细胞功能的影响.方法 将64例2型糖尿病患者分为门冬胰岛素30治疗组和甘精胰岛素治疗组,门冬胰岛素30组每日晚餐前注射一次,联合三餐后服二甲双胍或阿卡波糖；甘精胰岛素组睡前注射一次,联合三餐后服二甲双胍或阿卡波糖,观察治疗时间为12周.检测两组治疗前后空腹及餐后血糖、糖化血红蛋白(HbAlc)、C肽等指标,比较两组患者血糖控制情况及胰岛β细胞功能恢复情况.结果 门冬胰岛素30治疗组和甘精胰岛素治疗组在降糖,改善胰岛β细胞功能等方面比较差异无统计学意义,但甘精胰岛素组低血糖发生率低于门冬胰岛素30组(P＜0.01).结论 门冬胰岛素30和甘精胰岛素都具有明显的降低空腹和餐后血糖以及HbA1c的作用,用门冬胰岛素30方法联合二甲双胍或阿卡波糖治疗初诊2型糖尿病患者可以达到甘精胰岛素方法同样的效果.
目的 觀察每天註射一次門鼕胰島素30聯閤口服藥對初診2型糖尿病患者血糖控製及其對胰島β細胞功能的影響.方法 將64例2型糖尿病患者分為門鼕胰島素30治療組和甘精胰島素治療組,門鼕胰島素30組每日晚餐前註射一次,聯閤三餐後服二甲雙胍或阿卡波糖；甘精胰島素組睡前註射一次,聯閤三餐後服二甲雙胍或阿卡波糖,觀察治療時間為12週.檢測兩組治療前後空腹及餐後血糖、糖化血紅蛋白(HbAlc)、C肽等指標,比較兩組患者血糖控製情況及胰島β細胞功能恢複情況.結果 門鼕胰島素30治療組和甘精胰島素治療組在降糖,改善胰島β細胞功能等方麵比較差異無統計學意義,但甘精胰島素組低血糖髮生率低于門鼕胰島素30組(P＜0.01).結論 門鼕胰島素30和甘精胰島素都具有明顯的降低空腹和餐後血糖以及HbA1c的作用,用門鼕胰島素30方法聯閤二甲雙胍或阿卡波糖治療初診2型糖尿病患者可以達到甘精胰島素方法同樣的效果.
목적 관찰매천주사일차문동이도소30연합구복약대초진2형당뇨병환자혈당공제급기대이도β세포공능적영향.방법 장64례2형당뇨병환자분위문동이도소30치료조화감정이도소치료조,문동이도소30조매일만찬전주사일차,연합삼찬후복이갑쌍고혹아잡파당；감정이도소조수전주사일차,연합삼찬후복이갑쌍고혹아잡파당,관찰치료시간위12주.검측량조치료전후공복급찬후혈당、당화혈홍단백(HbAlc)、C태등지표,비교량조환자혈당공제정황급이도β세포공능회복정황.결과 문동이도소30치료조화감정이도소치료조재강당,개선이도β세포공능등방면비교차이무통계학의의,단감정이도소조저혈당발생솔저우문동이도소30조(P＜0.01).결론 문동이도소30화감정이도소도구유명현적강저공복화찬후혈당이급HbA1c적작용,용문동이도소30방법연합이갑쌍고혹아잡파당치료초진2형당뇨병환자가이체도감정이도소방법동양적효과.
Objective To investigate the therapeutic effect of combination of insulin aspart 30 injection and oral drugs for controling blood glucose and founction of islet β-cells in type 2 diabetic patients.Methods Sixty-four patients with type 2 diabetic were divided into two groups.Group insulin aspart 30 were injected with insulin aspart 30 once before supper,plus metformin or acarbose postprandial;Group insulin glargine were injected with insulin glargine once before asleep,plus metformin or acarbose postprandial.All patients were treated for 12 weeks.The values of FBS,PBS,HbAlc,C-peptide were periodically measured and compared.Results Both groups apparently decreased the glucose and improved the function of islet β-cells,there was no significant differences.But incidence of hypoglycemia in insulin glargine group was lower than that in insulin aspart 30 group(P＜0.01).Conclusions Insulin aspart 30 injection plus metformin or acarbose will achieved the same effects as the insulin glargine injection in treating type 2 diabetic patients.
