CAJ | 학술논문

以聚L-谷氨酸为载体材料,采用无水乳液法制备了口服胰岛素微球,微球直径在5～20 μm,载药质量分数为5%～9%.载药微球具有良好的pH敏感释放行为,在胃模拟液中2 h释放量约为5%,在肠道模拟液中2 h释放90%以上.考察聚合物分子量、溶液浓度、理论投药量及混合材料对微球释放行为的影响.
이취L-곡안산위재체재료,채용무수유액법제비료구복이도소미구,미구직경재5～20 μm,재약질량분수위5%～9%.재약미구구유량호적pH민감석방행위,재위모의액중2 h석방량약위5%,재장도모의액중2 h석방90%이상.고찰취합물분자량、용액농도、이론투약량급혼합재료대미구석방행위적영향.
Insulin-loaded poly(α,L-glutamic acid) microspheres for oral delivery were prepared by anhydrous emulsion system. The microspheres had diameters of 5-20 μm, and drug loading of 5%-9%. The microspheres had good pH sensitive release behavior. In gastric simulated fluid about 5% of insulin was released from microspheres after 2 h, while in intestinal simulated fluid over 90% of insulin released. The effect of polymer molecular weight, theoretical drug loading and polymer solution concentration to the microsphere release profile were investigated.