CAJ | 학술논문

目的研究胃腺癌组织中p53、E-cadherin的表达,分析它们和临床病理参数对预后的影响.方法采用组织芯片和免疫组化检测150例胃腺癌中p53、E-cadherin的表达,分析它们和临床病理参数对预后的影响.单因素分析用Kaplan-Meier法计算累积生存率并比较患者术后平均生存时间,多因素分析用COX回归.结果 150例胃腺癌中p53阳性率为31.3%;E-cadherin阳性率为91.3%.随访到的74例胃腺癌患者1年生存率为83.8%,3年生存率为70.3%,5年生存率为63.5%.单因素分析年龄、分化程度、Laurén分类、浸润深度、淋巴结状况、pTNM分期是影响胃腺癌预后的因素;多因素分析p53、年龄、淋巴结状况为影响胃腺癌预后的独立因素(P<0.05).结论 p53、年龄、分化程度、Laurén分类、浸润深度、淋巴结状况和pTNM分期是影响胃腺癌预后的因素,而E-cadherin和组织学分类不是影响胃腺癌预后的因素.
목적 연구위선암조직중p53、E-cadherin적표체,분석타문화림상병리삼수대예후적영향.방법 채용조직심편화면역조화검측150례위선암중p53、E-cadherin적표체,분석타문화림상병리삼수대예후적영향.단인소분석용Kaplan-Meier법계산루적생존솔병비교환자술후평균생존시간,다인소분석용COX회귀.결과 150례위선암중p53양성솔위31.3%;E-cadherin양성솔위91.3%.수방도적74례위선암환자1년생존솔위83.8%,3년생존솔위70.3%,5년생존솔위63.5%.단인소분석년령、분화정도、Laurén분류、침윤심도、림파결상황、pTNM분기시영향위선암예후적인소;다인소분석p53、년령、림파결상황위영향위선암예후적독립인소(P<0.05).결론 p53、년령、분화정도、Laurén분류、침윤심도、림파결상황화pTNM분기시영향위선암예후적인소,이E-cadherin화조직학분류불시영향위선암예후적인소.
Purpose To investigate the protein expression of p53 and E-cadherin in gastric adenocarcinoma and the effects of them and the clinicopathological parameters on prognosis of patients.Methods Expression of p53,E-cadherin in 150 cases of gastric adenocarcinoma was detected by tissue microarray and immunohistochemistry.The effects of them and the clinicopathological parameters on the prognosis of patients were studied by Kaplan-Meier method to calculate and compare the cumulative survival rate and postoperative mean survival time.Multivariate analysis was also performed by COX regression.Results The positive rate of p53 and E-cadherin expression in 150 cases of gastric adenocarcinoma was 31.3% and 91.3%,respectively.74 cases were followed up, and the 1-,3-,and 5-year survival rates were 83.8%,70.3% and 63.5%,respectively.The invasion, lymph node status and pTNM stages were prognostic factors;multivariate analysis revealed that p53,age and lymph node status were independent prognostic invasion, lymph node status and pTNM stages are important prognostic factors in gastric adenocarcinoma. Nevertheless, E-cadherin and histological classification are not prognostic factors.