CAJ | 학술논문

　　目的观察32 P-玻璃微球（32 P-GMS）的抑瘤效果及对外周血白细胞的影响。方法称重法检测32 P-GMS 对小鼠S180肉瘤的抑瘤率及对外周血白细胞计数和淋巴细胞分类的影响。结果32 P-GMS瘤内注射的抑瘤率分别为15．2％、20．4％、32．5％；治疗组小鼠随32 P-GMS剂量的增大，白细胞呈明显的上升趋势；各治疗组淋巴细胞分类百分率高于对照组，剂量超过0．74 MBq/mL有开始下降的趋势。结论32 P-GMS 瘤内注射有很强的抗肿瘤作用，但对外周血白细胞计数和淋巴细胞分类有明显影响。
　　목적관찰32 P-파리미구（32 P-GMS）적억류효과급대외주혈백세포적영향。방법칭중법검측32 P-GMS 대소서S180육류적억류솔급대외주혈백세포계수화림파세포분류적영향。결과32 P-GMS류내주사적억류솔분별위15．2％、20．4％、32．5％；치료조소서수32 P-GMS제량적증대，백세포정명현적상승추세；각치료조림파세포분류백분솔고우대조조，제량초과0．74 MBq/mL유개시하강적추세。결론32 P-GMS 류내주사유흔강적항종류작용，단대외주혈백세포계수화림파세포분류유명현영향。
Objective To observe anti-tumor function and effects on white blood cell counting of 32 P glass mi-crosphere (32 P-GMS) .Methods Inhibitory rate of 32 P-GMS on S180 sarcoma was calculated by using weighting method ,and the effects on white blood cell counting and lymphocyte classification were also analyzed .Results Inhibi-tory rates of intra-tumor injected 32 P-GMS with different dose of 0 .74 ,3 .7 and 18 .5 MBq/mL on S180 sarcoma were 15 .1% ,20 .3% and 32 .4% ,respectively .White blood cell counts could be increased with the increasing of the dose of 32 P-GMS .Lymphocyte percentage in treatment group was higher than model group .Conclusion 32 P-GMS could have effective anti-tumor function ,but also could effect the white blood cell level and lymphocyte classification .