国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2009年
6期
14-15
,共2页
ENKL%p33ING1%临床病理特点
ENKL%p33ING1%臨床病理特點
ENKL%p33ING1%림상병리특점
ENKL%p33ING1%Clinicopathological features
目的 探讨抑癌基因p33ING1在结外鼻型NK/T细胞淋巴瘤(下称ENKL)中的表达情况,研究ENKL的发病机制,寻找有助于判断预后的分子标志物.方法 用免疫组化方法检测p33ING1蛋白在37例ENKL和37例良性淋巴组织增牛中的表达,统计各蚩白表达与临床特点及生存期的关系.结果 37例良性淋巴组织增生p33ING1呈强阳性表达,在ENKL中的表达率约分别为67.57%(25/37),显著低于良性淋巴组织增生组(P＜0.01),p33ING1表达与LDH水平有关(P＜0.05).结论 p33ING1蛋白表达低下可促进ENKL的发生和发展.
目的 探討抑癌基因p33ING1在結外鼻型NK/T細胞淋巴瘤(下稱ENKL)中的錶達情況,研究ENKL的髮病機製,尋找有助于判斷預後的分子標誌物.方法 用免疫組化方法檢測p33ING1蛋白在37例ENKL和37例良性淋巴組織增牛中的錶達,統計各蚩白錶達與臨床特點及生存期的關繫.結果 37例良性淋巴組織增生p33ING1呈彊暘性錶達,在ENKL中的錶達率約分彆為67.57%(25/37),顯著低于良性淋巴組織增生組(P＜0.01),p33ING1錶達與LDH水平有關(P＜0.05).結論 p33ING1蛋白錶達低下可促進ENKL的髮生和髮展.
목적 탐토억암기인p33ING1재결외비형NK/T세포림파류(하칭ENKL)중적표체정황,연구ENKL적발병궤제,심조유조우판단예후적분자표지물.방법 용면역조화방법검측p33ING1단백재37례ENKL화37례량성림파조직증우중적표체,통계각치백표체여림상특점급생존기적관계.결과 37례량성림파조직증생p33ING1정강양성표체,재ENKL중적표체솔약분별위67.57%(25/37),현저저우량성림파조직증생조(P＜0.01),p33ING1표체여LDH수평유관(P＜0.05).결론 p33ING1단백표체저하가촉진ENKL적발생화발전.
Objective To study expressions of p33ING1 proteins in extranodal nasal type NK/T cell lymphoma(ENKL). Methods p33ING1 were detected by immunohistochemistry in 37 cases of ENKL and 37 cases of benign lymphoid tissue proliferation. Results Expressions of p33ING1 and in ENKL were 67.57%, lower than that in benign lymphoid tissue proliferation. Low expression of p33ING1 in ENKL was correlation to patients' high level LDH. Conclusions Low or lost expression of p33ING1 may play on important role on the development and progression of ENKL.
