中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
18期
4-6
,共3页
秃发%泼尼松%硫酸锌%米诺地尔
禿髮%潑尼鬆%硫痠鋅%米諾地爾
독발%발니송%류산자%미낙지이
Alopecia%Prednisone%Zinc sulfate%Minoxidil
目的 观察近生理剂量泼尼松、锌制剂联合2%米诺地尔治疗雄激素性秃发的临床疗效.方法 将98例雄激素性秃发患者按就诊先后1∶1比例,分为治疗组和对照组,治疗组口服近生理剂量泼尼松和自制锌制剂口服液联合2%米诺地尔酊外用,对照组仅口服近生理剂量泼尼松和自制锌制剂口服液.3个月为1个疗程,用药1～4个疗程分别观察疗效.结果 治疗后3、6个月治疗组有效率分别为10.2%(5/49)、36.7%(18/49),对照组分别为6.1%(3/49)、22.4%(11/49),两组比较差异无统计学意义(P＞0.05).治疗后9、12个月治疗组有效率分别为77.6%(38/49)、91.8%(45/49),对照组分别为42.9%(21/49)、59.2%(29/49),两组比较差异有统计学意义(P＜0.05).结论 近生理剂量泼尼松、锌制剂联合2%米诺地尔治疗雄激素性秃发的临床疗效满意,长期用药效果理想,安全性和耐受性良好.
目的 觀察近生理劑量潑尼鬆、鋅製劑聯閤2%米諾地爾治療雄激素性禿髮的臨床療效.方法 將98例雄激素性禿髮患者按就診先後1∶1比例,分為治療組和對照組,治療組口服近生理劑量潑尼鬆和自製鋅製劑口服液聯閤2%米諾地爾酊外用,對照組僅口服近生理劑量潑尼鬆和自製鋅製劑口服液.3箇月為1箇療程,用藥1～4箇療程分彆觀察療效.結果 治療後3、6箇月治療組有效率分彆為10.2%(5/49)、36.7%(18/49),對照組分彆為6.1%(3/49)、22.4%(11/49),兩組比較差異無統計學意義(P＞0.05).治療後9、12箇月治療組有效率分彆為77.6%(38/49)、91.8%(45/49),對照組分彆為42.9%(21/49)、59.2%(29/49),兩組比較差異有統計學意義(P＜0.05).結論 近生理劑量潑尼鬆、鋅製劑聯閤2%米諾地爾治療雄激素性禿髮的臨床療效滿意,長期用藥效果理想,安全性和耐受性良好.
목적 관찰근생리제량발니송、자제제연합2%미낙지이치료웅격소성독발적림상료효.방법 장98례웅격소성독발환자안취진선후1∶1비례,분위치료조화대조조,치료조구복근생리제량발니송화자제자제제구복액연합2%미낙지이정외용,대조조부구복근생리제량발니송화자제자제제구복액.3개월위1개료정,용약1～4개료정분별관찰료효.결과 치료후3、6개월치료조유효솔분별위10.2%(5/49)、36.7%(18/49),대조조분별위6.1%(3/49)、22.4%(11/49),량조비교차이무통계학의의(P＞0.05).치료후9、12개월치료조유효솔분별위77.6%(38/49)、91.8%(45/49),대조조분별위42.9%(21/49)、59.2%(29/49),량조비교차이유통계학의의(P＜0.05).결론 근생리제량발니송、자제제연합2%미낙지이치료웅격소성독발적림상료효만의,장기용약효과이상,안전성화내수성량호.
Objective To investigate the clinical effect of prednisone and zinc preparation combined with 2％ minoxidil in the androgenetic alopecia. Methods Ninety-eight patients with the androgenetic alopecia were randomly divided into two groups, each group was 49 patients. The treatment group received prednisone and zinc preparation oral solution combined with 2％ minoxidil, the control group received only prednisone and zinc preparation oral solution. The each course of treatment was 3 months, the effect was observed after 1-4 courses of treatment. Results The curative rate of the treatment group and control group were 10.2％( 5/49 ) ,36.7％ (18/49) and 6.1％ (3/49) ,22.4％ (11/49) respectively in 3 and 6 months after treatment, there were no significant difference between two groups (P ＞ 0.05 ). The curative rate of the treatment group and control group were 77.6％ (38/49), 91.8％ (45/49) and 42.9％ (21/49 ), 59.2％(29/49) respectively in 9 and 12 months after treatment, there were significant difference between two groups (P＜ 0.05). Conclusion On treating the androgenetic alopecia, prednisone and zinc preparation combined with minoxidilis effective and safe.
