国际生物制品学杂志
國際生物製品學雜誌
국제생물제품학잡지
INTERNATIONAL JOURNAL OF BIOLOGICALS
2009年
1期
4-6
,共3页
肝炎疫苗,乙型%肝炎表面抗原,乙型%肝炎抗体,乙型%接种
肝炎疫苗,乙型%肝炎錶麵抗原,乙型%肝炎抗體,乙型%接種
간염역묘,을형%간염표면항원,을형%간염항체,을형%접충
Hepatitis B vaccines%Hepatitis B surface antigens%Hepatitis B antibodies:Vaccination
目的 了解健康人群乙型肝炎(乙肝)疫苗接种情况,评价乙肝预防效果,为制定免疫策略提供依据.方法 按照两阶段抽样法,在马鞍山市三区一县抽取8个行政村1-59岁常住人口2038人,进行问卷调查,并采集静脉血,用ELISA法检测乙肝血清标志物.率的比较采用卡方检验.结果 乙肝疫苗调查接种率为50.54%,城市高于农村,低年龄组(98.14%)到高年龄组(0.95%)逐渐降低,男性高于女性.散居和托幼儿童接种率最高(96.58%和98.77%),学生次之(87.17%),农民最低(4.26%).1～59岁人群HBsAg阳性率从低年龄组到高年龄组逐渐增高(O%-10.48%),抗-HBs阳性率为14.58%-50.18%,15-岁组最低(14.58%).1990-2007年间乙肝报告发病率以1999年最高,为67.0660/10万,之后呈逐年下降趋势.2005-2007年平均乙肝报告发病率在≤14岁的人群中低于4.6731/10万,在≥15岁的人群中高于32.0789/10万.乙肝血源疫苗接种后HBsAg和抗-HBs阳性率分别为0.98%和39.54%,与基因工程疫苗接种后阳性率(0.49%和43.28%)的差异无统计学意义(x2=0.107,P=0.744;x2=1.004,P=0.316).结论 应继续开展新生儿乙肝疫苗接种,推广成年人接种,并将预防乙肝资源向农村倾斜.
目的 瞭解健康人群乙型肝炎(乙肝)疫苗接種情況,評價乙肝預防效果,為製定免疫策略提供依據.方法 按照兩階段抽樣法,在馬鞍山市三區一縣抽取8箇行政村1-59歲常住人口2038人,進行問捲調查,併採集靜脈血,用ELISA法檢測乙肝血清標誌物.率的比較採用卡方檢驗.結果 乙肝疫苗調查接種率為50.54%,城市高于農村,低年齡組(98.14%)到高年齡組(0.95%)逐漸降低,男性高于女性.散居和託幼兒童接種率最高(96.58%和98.77%),學生次之(87.17%),農民最低(4.26%).1～59歲人群HBsAg暘性率從低年齡組到高年齡組逐漸增高(O%-10.48%),抗-HBs暘性率為14.58%-50.18%,15-歲組最低(14.58%).1990-2007年間乙肝報告髮病率以1999年最高,為67.0660/10萬,之後呈逐年下降趨勢.2005-2007年平均乙肝報告髮病率在≤14歲的人群中低于4.6731/10萬,在≥15歲的人群中高于32.0789/10萬.乙肝血源疫苗接種後HBsAg和抗-HBs暘性率分彆為0.98%和39.54%,與基因工程疫苗接種後暘性率(0.49%和43.28%)的差異無統計學意義(x2=0.107,P=0.744;x2=1.004,P=0.316).結論 應繼續開展新生兒乙肝疫苗接種,推廣成年人接種,併將預防乙肝資源嚮農村傾斜.
목적 료해건강인군을형간염(을간)역묘접충정황,평개을간예방효과,위제정면역책략제공의거.방법 안조량계단추양법,재마안산시삼구일현추취8개행정촌1-59세상주인구2038인,진행문권조사,병채집정맥혈,용ELISA법검측을간혈청표지물.솔적비교채용잡방검험.결과 을간역묘조사접충솔위50.54%,성시고우농촌,저년령조(98.14%)도고년령조(0.95%)축점강저,남성고우녀성.산거화탁유인동접충솔최고(96.58%화98.77%),학생차지(87.17%),농민최저(4.26%).1～59세인군HBsAg양성솔종저년령조도고년령조축점증고(O%-10.48%),항-HBs양성솔위14.58%-50.18%,15-세조최저(14.58%).1990-2007년간을간보고발병솔이1999년최고,위67.0660/10만,지후정축년하강추세.2005-2007년평균을간보고발병솔재≤14세적인군중저우4.6731/10만,재≥15세적인군중고우32.0789/10만.을간혈원역묘접충후HBsAg화항-HBs양성솔분별위0.98%화39.54%,여기인공정역묘접충후양성솔(0.49%화43.28%)적차이무통계학의의(x2=0.107,P=0.744;x2=1.004,P=0.316).결론 응계속개전신생인을간역묘접충,추엄성년인접충,병장예방을간자원향농촌경사.
Objective To evaluate the effect of hepatitis B vaccination in healthy people and provide the basis for developing immunization strategy.Methods Two-stage sampling method was designed.A questionnaire survey was conducted among 2038 permanent residents aged 1-59 years old from 8 villages.Intravenous blood samples were taken and detected for hepatitis B virus serum markers by ELISA.Results The surveyed inoculation rate of hepatitis B vaccine was 50.54%,with the rate being higher in urban area than in rural area and being higher in men than in women.The vaccination rate decreased gradually from the youngest group(98.14%)to the oldest group(0.95%).The scattered and nursery children had the highest rate (96.58%and 98.77%),followed by students(87.17%),farmers had the lowest rate(4.26%).HBsAg positive rates increased gradually from the youngest group to the oldest one(0%-10.48%).Anti-HBs positive rates were between 14.58%-50.18%,with 15-year old group having the lowest rate(14.58%).The reported incidence rate of hepatitis B was the highest in 1999(67.0660/100 000)from 1990 to 2007,and showed a descending tendency since then.The average reported incidence rate wag lower than 4.673 1/100 000 among age groups 14 years and under and was higher than 32.0789/100 000 among age groups 15 years and above between 2005 and 2007.HBsAg and anti-HBs positive rates after vaccination with plasma-derived hepatitis B vaccine(0.98%and 39.54%)had no statistical difference from those vaccinated with genetically engineered vaccine(0.49%and 43.28%)(x2=0.107,P=0.744;x2=1.004,P=0.316).ConclusionsWe should continue hepatitis B vaccination for neonates,expand adult hepatitis B vaccination and allocate more resources of hepatitis B prevention to the rural.
