CAJ | 학술논문

目的探讨代谢综合征与良性前列腺增生症(BPH)临床进展的相关性.方法选择382例伴有下尿路症状的BPH患者,按有无诊断为代谢综合征(MS)分为两组.MS的诊断依据2005年国际糖尿病联盟(IDF)所确定的标准.比较两组患者体质指数、腰臀围比值、血生化、血压、血糖等指标与BPH临床进展的相关性.经腹B超测量前列腺总体积(TP)并计算其年均增长率.结果 382例BPH患者中合并MS者187例(48.59%),表现为较高的体质指数、高血糖、高甘油三酯和高国际前列腺症状评分(IPSS)、前列腺体积(TP)、前列腺特异抗原(PSA)水平,以及较高的手术发生率(P＜0.05);其TP年均增长率亦显著高于无MS合并者(1.0与0.64 ml/y,P＜0.05).TP年均增长率和IPSS评分均与血糖、甘油三酯水平呈显著相关性(P＜0.01).结论代谢综合征是BPH临床进展的危险因素之一,临床需予以关注.
목적 탐토대사종합정여량성전렬선증생증(BPH)림상진전적상관성.방법 선택382례반유하뇨로증상적BPH환자,안유무진단위대사종합정(MS)분위량조.MS적진단의거2005년국제당뇨병련맹(IDF)소학정적표준.비교량조환자체질지수、요둔위비치、혈생화、혈압、혈당등지표여BPH림상진전적상관성.경복B초측량전렬선총체적(TP)병계산기년균증장솔.결과 382례BPH환자중합병MS자187례(48.59%),표현위교고적체질지수、고혈당、고감유삼지화고국제전렬선증상평분(IPSS)、전렬선체적(TP)、전렬선특이항원(PSA)수평,이급교고적수술발생솔(P＜0.05);기TP년균증장솔역현저고우무MS합병자(1.0여0.64 ml/y,P＜0.05).TP년균증장솔화IPSS평분균여혈당、감유삼지수평정현저상관성(P＜0.01).결론 대사종합정시BPH림상진전적위험인소지일,림상수여이관주.
Objective To assess the correlation between metabolic syndrome and clinical progression in patients with benign prostatic hyperplasia (BPH). Methods A total of 382 BPH patients with lower urinary tract symptoms were divided into two groups according to whether or not there was a diagnosis of metabolic syndrome (MS). MS was defined by the International Diabetes Federation (IDF) in 2005. Abdominal B-ultrasound was used to measure the total volume of prostate (TP) and its average annual growth rate was calculated. Body mass index, waist-hip ratio, blood biochemistry, blood pressure, blood glucose and other indicators were compared in these two groups of patients with regards to the clinical progression associated with BPH. Results A total of 187 MS cases were found in 382 (48.59%) BPH patients. It showed a higher body mass index, high glycemia, high triglycerides, high blood pressure and high IPSS, TP and PSA levels. Also it showed a higher occurrence of surgical rate ( P <0.05 ); its average annual growth rate of TP was significantly higher than those without MS ( 1.0 vs 0.64 ml/yr, P < 0.05 ). TP average annual growth rate and IPSS score are found significantly correlated with blood glucose and triglyceride levels (P <0.01 ). Conclusion Metabolic syndrome affects the clinical progression in patients with BPH. Clinical attention should be paid.