CAJ | 학술논문

目的研究血浆同型半胱氨酸(Hcy)水平与老年人脑梗死的关系.方法测定92例老年人脑梗死患者,其中腔隙性脑梗死(脑小动脉病变型)24例,单发脑梗死(脑大动脉病变型)52例,复发性脑梗死16例和30例健康对照者空腹血浆Hcy、叶酸及维生素B12水平.结果单发脑梗死组、复发性脑梗死组血浆Hcy水平显著高于对照组(P＜0.Ol).而腔隙性脑梗死组与对照组比较差异无统计学意义(P＞0.05),且复发性脑梗死组显著高于单发脑梗死组(P＜0.05).单发脑梗死组、复发性脑梗死组血浆叶酸及维生素B12水平显著低于对照组(P＜O.01),而腔隙性脑梗死组与对照组比较差异无统计学意义(P＞0.05),且复发性脑梗死组显著低于单发脑梗死纽(P＜0.05).结论高Hcy血症与老年人脑梗死的危险性增加有关,且与脑动脉粥样硬化性大血管病变有较强联系,并可能是脑梗死复发的一个独立危险因素；血浆Hey水平和叶酸、维生素B12浓度呈负相关.
목적 연구혈장동형반광안산(Hcy)수평여노년인뇌경사적관계.방법 측정92례노년인뇌경사환자,기중강극성뇌경사(뇌소동맥병변형)24례,단발뇌경사(뇌대동맥병변형)52례,복발성뇌경사16례화30례건강대조자공복혈장Hcy、협산급유생소B12수평.결과 단발뇌경사조、복발성뇌경사조혈장Hcy수평현저고우대조조(P＜0.Ol).이강극성뇌경사조여대조조비교차이무통계학의의(P＞0.05),차복발성뇌경사조현저고우단발뇌경사조(P＜0.05).단발뇌경사조、복발성뇌경사조혈장협산급유생소B12수평현저저우대조조(P＜O.01),이강극성뇌경사조여대조조비교차이무통계학의의(P＞0.05),차복발성뇌경사조현저저우단발뇌경사뉴(P＜0.05).결론 고Hcy혈증여노년인뇌경사적위험성증가유관,차여뇌동맥죽양경화성대혈관병변유교강련계,병가능시뇌경사복발적일개독립위험인소；혈장Hey수평화협산、유생소B12농도정부상관.
Objective To study the relationship between plasma homocystine level and cerebral infarction(CI) in elderly patients.Methods The plasma Hey,folacin and vitamin B12 levels of 92 CI patients,including 24 cases of lacunarinfarction( small-arterydisease),52 cases of single cerebral infarction (large-artery disease),16 cases of recurrent cerebral infarction and 30 cases of healthy controls in elderly patients.Results Plasma levels of Hcy in single cerebral infarction and recurrent cerebral infarction group were significantly higher than that in control group (P＜0.01 ),but there were no significant differences between lacunar infarction group and the control group (P ＞O.05 ),and that in recurrent cerebral infarction group was significantly higher than single cerebral infarction group ( P ＜0.05 ).Plasma levels of folacin and vitamin B12 in single cerebral infarction group and recurrent cerebral infarction group were significantly lower than those in control group (P ＜ 0.01 ),but there were no significant differences between lacunarinfaretion group and control group ( P ＞ O.05 ),and that in recurrent cerebral infarction group was significantly lower than single cerebral infarction group (P ＜0.05 ).Conclusions Hyperhomocysteinemia is associated with the increased risk of cerebral infarction,and there is a strong association between elevated homocystine and atherosclerotic vascular disease.Hyperhomocysteinemia maybe an independent risk factor of recurrent cerebral infarction; Plasma Hcy and folic acid,vitamin B12 concentrations are negatively correlated.