中华消化内镜杂志
中華消化內鏡雜誌
중화소화내경잡지
CHINESE JOURNAL OF DIGESTIVE ENDOSCOPY
2010年
7期
356-359
,共4页
肥胖症%糖尿病,2型%大肠腺瘤%大肠腺癌
肥胖癥%糖尿病,2型%大腸腺瘤%大腸腺癌
비반증%당뇨병,2형%대장선류%대장선암
Obesity%Diabetes mellitus,type 2%Colorectal adenoma%Colorectal adencarcinoma
目的 初步探讨体质量指数(BMI)、2型糖尿病与大肠腺瘤腺癌的相关性.方法 2008年7月至2009年7月间,选择年龄为20～86岁的大肠镜检查患者971例,测量身高、体重,并记录有无糖尿病及病程.根据肠镜检查及活检病理结果纳入研究组(即腺瘤腺癌组,总计471例)和正常对照组(500例).利用多因素Logistic回归进行相关性分析.结果 调整了可能的混杂因素后,肥胖组患大肠腺瘤腺癌的危险度是正常组的2.55倍,其中肥胖组男性患大肠腺瘤腺癌的危险度是正常组的3.32倍,而女性中不同BMI指数大肠腺瘤腺癌的患病率差异无统计学意义.超重组差异无统计学意义.2型糖尿病的患者引起大肠腺瘤腺癌的危险度是无糖尿病患者的约2.10倍,其中,病程<6年引起大肠腺瘤腺癌的危险度是病程≥6年的约3.00倍,且风险与性别无关.糖尿病合并肥胖患者患大肠腺瘤腺癌的危险度是糖尿病无合并肥胖患者的3.05倍.结论 肥胖与大肠腺瘤腺癌的发生显著相关,肥胖男性患病风险明显大于女性.2型糖尿病患者患大肠腺瘤腺癌的风险较高,且糖尿病合并肥胖的患者患大肠腺瘤腺癌的风险显著高于糖尿病无肥胖的患者.
目的 初步探討體質量指數(BMI)、2型糖尿病與大腸腺瘤腺癌的相關性.方法 2008年7月至2009年7月間,選擇年齡為20～86歲的大腸鏡檢查患者971例,測量身高、體重,併記錄有無糖尿病及病程.根據腸鏡檢查及活檢病理結果納入研究組(即腺瘤腺癌組,總計471例)和正常對照組(500例).利用多因素Logistic迴歸進行相關性分析.結果 調整瞭可能的混雜因素後,肥胖組患大腸腺瘤腺癌的危險度是正常組的2.55倍,其中肥胖組男性患大腸腺瘤腺癌的危險度是正常組的3.32倍,而女性中不同BMI指數大腸腺瘤腺癌的患病率差異無統計學意義.超重組差異無統計學意義.2型糖尿病的患者引起大腸腺瘤腺癌的危險度是無糖尿病患者的約2.10倍,其中,病程<6年引起大腸腺瘤腺癌的危險度是病程≥6年的約3.00倍,且風險與性彆無關.糖尿病閤併肥胖患者患大腸腺瘤腺癌的危險度是糖尿病無閤併肥胖患者的3.05倍.結論 肥胖與大腸腺瘤腺癌的髮生顯著相關,肥胖男性患病風險明顯大于女性.2型糖尿病患者患大腸腺瘤腺癌的風險較高,且糖尿病閤併肥胖的患者患大腸腺瘤腺癌的風險顯著高于糖尿病無肥胖的患者.
목적 초보탐토체질량지수(BMI)、2형당뇨병여대장선류선암적상관성.방법 2008년7월지2009년7월간,선택년령위20～86세적대장경검사환자971례,측량신고、체중,병기록유무당뇨병급병정.근거장경검사급활검병리결과납입연구조(즉선류선암조,총계471례)화정상대조조(500례).이용다인소Logistic회귀진행상관성분석.결과 조정료가능적혼잡인소후,비반조환대장선류선암적위험도시정상조적2.55배,기중비반조남성환대장선류선암적위험도시정상조적3.32배,이녀성중불동BMI지수대장선류선암적환병솔차이무통계학의의.초중조차이무통계학의의.2형당뇨병적환자인기대장선류선암적위험도시무당뇨병환자적약2.10배,기중,병정<6년인기대장선류선암적위험도시병정≥6년적약3.00배,차풍험여성별무관.당뇨병합병비반환자환대장선류선암적위험도시당뇨병무합병비반환자적3.05배.결론 비반여대장선류선암적발생현저상관,비반남성환병풍험명현대우녀성.2형당뇨병환자환대장선류선암적풍험교고,차당뇨병합병비반적환자환대장선류선암적풍험현저고우당뇨병무비반적환자.
Objective To investigate the correlation between body mass index ( BMI) , type Ⅱ diabetes and colorectal neoplastic lesions including adenoma and adenocarcinoma. Methods A total of 971 subjects, aged 20-86, who underwent colonoscopy from July 2008 to July 2009 were included. The body height and weight were measured, and history of type Ⅱ diabetes was recorded. Based on the results of colonoscopy and pathology, the subjects were divided into study group (with confirmed adenoma or adenocarcinoma; n =471) and normal control group (n = 500). All data were analyzed by using logistic multi-factors regression. Results With adjustment for some potential mixed factors, obesity group run 2. 55 times of risk of colorectal adenoma or adencarcinoma compared with the normal weight group (OR = 2.55, 95% CI: 1.26-3.05, P =0.027), among which obese male's risk was 3. 32 (OR =3.32, 95% CI: 1. 50-6. 86, P = 0.007) times of that in normal weight males. There was no correlation between female's BMI and incidence of colorectal adenoma & adencarcinoma. Patients with type Ⅱ diabetes ran 2. 10 times of risk of developing colorectal neoplastic lesions compared with those without ( OR = 2.10, 95% CI: 1. 25 - 3. 57, P = 0.010). Incidence of colorectal adenoma & adencarcinoma was 3 times higher in those with type II diabetes less than 6 years, compared with those with history more than 6 years ( OR = 3.00, 95% CI: 1.05 - 10. 86, P =0. 040), which was not correlated with gender of diabetic patients. Those with both type Ⅱ diabetes and obesity had 3.05 times of risk of colorectal adenoma & adencarcinoma, compared with non-obese diabetic patients (OR = 3.05,95% CI: 1.08 - 18.41, P - 0.041). Conclusion Obesity is positively correlated with colorectal adenoma and adencarcinoma, and obese males run higher risk than females. Type Ⅱ diabetes also leads to a higher incidence of colorectal neoplastic lesions, which will run even higher when combined with o-besity.
