CAJ | 학술논문

[目的]对比研究顺式阿曲库铵在主动脉瓣关闭不全(AI)中重度主动脉瓣返流患者诱导阶段药效学的改变.[方法]30例患者纳入此项研究中:实验组选择主动脉瓣关闭不全,中重度返流择期行主动脉瓣瓣膜替换术患者15例(AI组).另选择15例行普通外科手术的非心脏病患者作为对照组(C组).两组患者均给于芬太尼5μg/kg+异丙酚0.5～2 mg/kg+顺式阿曲库铵0.1 mg/kg(2倍ED_(95))麻醉诱导,麻醉维持采用异丙酚+瑞芬太尼的全凭静脉麻醉方式.应用TOF-WATCH SX加速度仪记录顺式阿曲库铵的起效时间、无反应时间、临床作用时间及恢复指数.[结果]AI组的起效时间(min)较C组明显延长(5.6±0.8 vs 3.4±0.4,P＜0.001).两组患者的恢复时间和恢复指数差异没有显著性.[结论]顺式阿曲库铵用于中重度主动脉关闭不全患者的麻醉诱导,和对照组比较药物起效时间明显延长,但持续时间恢复指数并没有区别.
[목적]대비연구순식아곡고안재주동맥판관폐불전(AI)중중도주동맥판반류환자유도계단약효학적개변.[방법]30례환자납입차항연구중:실험조선택주동맥판관폐불전,중중도반류택기행주동맥판판막체환술환자15례(AI조).령선택15례행보통외과수술적비심장병환자작위대조조(C조).량조환자균급우분태니5μg/kg+이병분0.5～2 mg/kg+순식아곡고안0.1 mg/kg(2배ED_(95))마취유도,마취유지채용이병분+서분태니적전빙정맥마취방식.응용TOF-WATCH SX가속도의기록순식아곡고안적기효시간、무반응시간、림상작용시간급회복지수.[결과]AI조적기효시간(min)교C조명현연장(5.6±0.8 vs 3.4±0.4,P＜0.001).량조환자적회복시간화회복지수차이몰유현저성.[결론]순식아곡고안용우중중도주동맥관폐불전환자적마취유도,화대조조비교약물기효시간명현연장,단지속시간회복지수병몰유구별.
[Objective]The purpose of this study was to investigate the effect of severe aortic valve incompetence on the pharmacodynamics of cisatracurium.[Methods]Thirty patients were enrolled in this study:15 patients with severe aortic valve incompetence scheduled for aortic valve replacement were included in the study group(AI-group)and 15 patients without heart disease undergoing general surgical operations were allocated into the control group(C-group).Anesthesia was induced with fentanyl 5 μg/kg.propofol 1.5～2 mg/kg and cisatracurium 0.1 mg/kg and maintained by total intravenous anesthesia with propofol-remifentanil infusion.Degree of neuromuscular block was measured by train-of-four ratio using TOF-WATCH acceleragraph monitor.Onset time(from administration of cisatracurium to T1=0),total twitch suppression time,the time for spontaneous recovery of T1 to 25%and 75%.and the recovery index were recorded respectively.[Results]The onset time of cisatracurium was significantly longer in the AI group compared to the control group(5.6±0.8 min vs 3.4 ±0.4 min.P＜0.001.However.there was no difference in the recovery time between the two groups.[Conclusion]We demonstrated that the onset of cisatracurium was delayed in the patients with severe aortic regurgitation in comparison to those without heart disease.