CAJ | 학술논문

目的建立适于研究压疮预防护理的动物模型.方法健康雄性SD大鼠30只,随机分为6组,每组5只,麻醉后使其仰卧于设计好的简易加压装置,以大鼠后肢关节为压迫点,每组的压力大小分别为70,64,58,53,48,44mm Hg,持续作用2 h后,观察受压部位皮肤的外观改变,并应用寇氏法(K(a)rbar氏法)计算使半数动物受压部位皮肤发红的压强.结果各组均未出现肉眼可见的皮肤破损等严重变化,但受压局部皮肤肉眼观察可见发红现象.在此实验条件下,使半数动物皮肤发红的压强大小为55.08 mm Hg.结论在此装置下,建立这个模型最合适的压强应为55.08 mm Hg.以此压强建立的SD大鼠动物模型方法简单易行,可应用于预防压疮护理的动物实验研究.
목적 건립괄우연구압창예방호리적동물모형.방법 건강웅성SD대서30지,수궤분 위6조,매조5지,마취후사기앙와우설계호적간역가압장치,이대서후지관절위압박점,매조적압력대소분별위70,64,58,53,48,44mm Hg,지속작용2 h후,관찰수압부위피부적외관개변,병응용구씨법(K(a)rbar씨법)계산사반수동물수압부위피부발홍적압강.결과 각조균미출현육안가견적피부파손등엄중변화,단수압국부피부육안관찰가견발홍현상.재차실험조건하,사반수동물피부발홍적압강대소위55.08 mm Hg.결론 재차장치하,건립저개모형최합괄적압강응위55.08 mm Hg.이차압강건립적SD대서동물모형방법간단역행,가응용우예방압창호리적동물실험연구.
Objective To establish an SD rats animal model for preventive nursing of pressure ulcer.Methods 30 healthy male SD rats were randomly and averagely divided into 6 groups, which were put in simple compression devices supinely after anesthesia, with their hind limb joints regarded as oppressed points.The pressure of each group was: 70, 64, 58, 53, 48 and 44mmHg, respectively. By observing skin color change after two hours of compression and then calculating LD50, the pressure that made half animals' compression skin red was obtained. Results No group had visible skin damages and other serious changes, but compression local skin redness was found. Under the experimental conditions, the pressure of the skin redness among half of the animals was 55.08 mmHg. Conclusions In this model, the most appropriate pressure was 55.08 mmHg. The SD rats pressure ulcer animal model is feasible and could be applied to animal studies on preventive nursing of pressure ulcer.