CAJ | 학술논문

对11例肾母细胞瘤组织进行了电镜和光镜观察,结果9例可见淋巴细胞浸润在瘤细胞之间,其中4例淋巴细胞邻近的瘤细胞有不同程度的溶解现象.淋巴细胞表面可见足状突起与瘤细胞接触,相应瘤细胞膜出现缺失,淋巴细胞则保持质膜完整.观察结果为认识肾母细胞瘤机体抗肿瘤免疫反应提供了形态学依据.
대11례신모세포류조직진행료전경화광경관찰,결과9례가견림파세포침윤재류세포지간,기중4례림파세포린근적류세포유불동정도적용해현상.림파세포표면가견족상돌기여류세포접촉,상응류세포막출현결실,림파세포칙보지질막완정.관찰결과위인식신모세포류궤체항종류면역반응제공료형태학의거.
Histopathological changes of nephroblastoma were studied in 11 cases under electron and light microscopy.In ultrastructtual view,the lymphocytes were found to be attached to the oncocytes by their pseudopodia in 9 cases.Only in 4 cases,however,the oncocyte membrance and cytoplasm adjacent to the lymphocytes were damaged,but the lymphocytes were intact.According to the similar studies of adult malignancies,the phenomenon of infiltrating lymphocytemediated oncocyte lysis probably reflects the presence of antitumor response in nephroblastoma.The study reveals a direct morphologic evidence that the infiltrating lymphocytes may be cytotoxic to the oncocytes in some nephroblastoma cases.