中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2011年
9期
775-777
,共3页
苗宗玉%杨刚毅%李伶%孙滨%刘瑞%卢春敏%张志红%徐胜男%杜林
苗宗玉%楊剛毅%李伶%孫濱%劉瑞%盧春敏%張誌紅%徐勝男%杜林
묘종옥%양강의%리령%손빈%류서%로춘민%장지홍%서성남%두림
利拉鲁肽%低脂联素血症%成纤维细胞生长因子21
利拉魯肽%低脂聯素血癥%成纖維細胞生長因子21
리랍로태%저지련소혈증%성섬유세포생장인자21
Liraglutide%Hypoadiponectinemia%Fibroblast growth factor-21
探讨利拉鲁肽(liraglutide)对低脂联素血症载脂蛋白E基因敲除（ApoE-/-）小鼠糖脂代谢和成纤维细胞生长因子21( FGF-21)及其受体(FGFR)的影响。低脂联素血症加重了ApoE-/-小鼠糖脂代谢紊乱和胰岛素抵抗，并导致了肝脏和脂肪组织FGF-21 mRNA和蛋白表达及血浆FGF-21水平明显升高，脂肪组织FGFR1和β-klotho表达降低，肝脏FGFR 1-3和β-klotho均降低。利拉鲁肽干预在改善小鼠糖脂代谢紊乱和胰岛素敏感性的同时部分逆转了FGF-21及其受体的改变。
探討利拉魯肽(liraglutide)對低脂聯素血癥載脂蛋白E基因敲除（ApoE-/-）小鼠糖脂代謝和成纖維細胞生長因子21( FGF-21)及其受體(FGFR)的影響。低脂聯素血癥加重瞭ApoE-/-小鼠糖脂代謝紊亂和胰島素牴抗，併導緻瞭肝髒和脂肪組織FGF-21 mRNA和蛋白錶達及血漿FGF-21水平明顯升高，脂肪組織FGFR1和β-klotho錶達降低，肝髒FGFR 1-3和β-klotho均降低。利拉魯肽榦預在改善小鼠糖脂代謝紊亂和胰島素敏感性的同時部分逆轉瞭FGF-21及其受體的改變。
탐토리랍로태(liraglutide)대저지련소혈증재지단백E기인고제（ApoE-/-）소서당지대사화성섬유세포생장인자21( FGF-21)급기수체(FGFR)적영향。저지련소혈증가중료ApoE-/-소서당지대사문란화이도소저항，병도치료간장화지방조직FGF-21 mRNA화단백표체급혈장FGF-21수평명현승고，지방조직FGFR1화β-klotho표체강저，간장FGFR 1-3화β-klotho균강저。리랍로태간예재개선소서당지대사문란화이도소민감성적동시부분역전료FGF-21급기수체적개변。
The effects of liraglutide on glucose and lipid metabolism, fibroblast growth factor-21 ( FGF-21 )and its receptors (FGFR) in APoE-/-mice with hypoadiponectinemia were investigated. Hypoadiponectinemia facilitated disturbance in glucose and lipid metabolism and insulin resistance. Compared with the control mice, FGF21 mRNA and protein expressions of liver and adipose tissues as well as plasma FGF-21 level were significantly increased in ApoE-/-mice with hypoadiponectinemia, along with lowered expressions of FGFR1 and β-klotho mRNA in adipose tissues, and expressions of FGFR1-3 and β-klotho mRNA in liver. Liraglutide administration improved glucose and lipid metabolism and insulin resistance, and partially reversed the changes of FGF-21 and its receptors induced by hypoadiponectinemia.
