中南药学
中南藥學
중남약학
CENTRAL SOUTH PHARMACY
2009年
7期
521-522
,共2页
彭锋%邱晓敏%冯颂延%林丽薇%陈洁斌
彭鋒%邱曉敏%馮頌延%林麗薇%陳潔斌
팽봉%구효민%풍송연%림려미%진길빈
普卢利沙星%中间体%3,4-二氟苯基异硫氰酸酯%N,N-二(3,4-二氟苯基)硫脲
普盧利沙星%中間體%3,4-二氟苯基異硫氰痠酯%N,N-二(3,4-二氟苯基)硫脲
보로리사성%중간체%3,4-이불분기이류청산지%N,N-이(3,4-이불분기)류뇨
pruliflouroxacin%intermediates%3,4-diflorophenyl isothiocyanate%N,N-bis[3,4-diflourphenyl]thioura
目的 开发出一条新的环保工艺代替文献报导的卡卢扎反应,制备3,4-二氟苯基异硫氰酸酯.方法 3,4-二氟苯胺与二硫化碳在氢氧化钠水溶液中反应1 h,制得新的中间体N,N-二(3,4-二氟苯基)硫脲,后者在醋酐中加热分解得到1分子的目标物和1分子3,4-二氟苯基乙酰胺,副产物可以回收再使用.结果 得到3,4-二氟苯基异硫氰酸酯,收率为40%.结论 新工艺无需使用氯甲酸乙酯,避免了原工艺长时间的低温控制.
目的 開髮齣一條新的環保工藝代替文獻報導的卡盧扎反應,製備3,4-二氟苯基異硫氰痠酯.方法 3,4-二氟苯胺與二硫化碳在氫氧化鈉水溶液中反應1 h,製得新的中間體N,N-二(3,4-二氟苯基)硫脲,後者在醋酐中加熱分解得到1分子的目標物和1分子3,4-二氟苯基乙酰胺,副產物可以迴收再使用.結果 得到3,4-二氟苯基異硫氰痠酯,收率為40%.結論 新工藝無需使用氯甲痠乙酯,避免瞭原工藝長時間的低溫控製.
목적 개발출일조신적배보공예대체문헌보도적잡로찰반응,제비3,4-이불분기이류청산지.방법 3,4-이불분알여이류화탄재경양화납수용액중반응1 h,제득신적중간체N,N-이(3,4-이불분기)류뇨,후자재작항중가열분해득도1분자적목표물화1분자3,4-이불분기을선알,부산물가이회수재사용.결과 득도3,4-이불분기이류청산지,수솔위40%.결론 신공예무수사용록갑산을지,피면료원공예장시간적저온공제.
Objective To develop an environmental new preparation technology for 3,4-diflorophenyl isothiocyanate, an important immediate of prulifolxacin.Methods 3,4-diflouroalline was condensed with CS2 in NaOH to prepare N,N-bis[3,4-diflourphenyl] thiourea which was acidolysis in hot (AcO)2O to give the tittle compound, the main vice-product 3,4-diflouroalline acetate can be recycled. N,N-bis[3,4-diflourphenyl]thiourea was a novel intermediate.Results Obtained 3,4-diflourphenyl isothiocyanate with overall yield of 40%.Conclusion An environmental new preparation technology is studied in which ethyl formate chloride is substituted, and conditions such as long-time and low-temperature are not necessary.
