CAJ | 학술논문

基于蒽醌类药物在碱性条件下对高碘酸钾-鲁米诺化学发光体系的化学发光信号有强烈的抑制作用这一现象,结合流动注射技术建立了一种直接测定蒽醌类药物的流动注射化学发光分析新方法.该方法测定大黄素的线性范围为1.0×10~(-8)-3.0×10~(-7)g/mL,检出限为2×10~(-9)g/mL,测定大黄酸的线性范围为7.0×10~(-8)-3.0×10~(-6)g/mL,检出限为2×10~(-8)g/mL;测定大黄素甲醚的线性范围为1.0×10~(-9)-5.0×10~(-8)g/mL,检出限为3×10~(-10)g/mL.该方法操作简单快速、灵敏度高,可用于样品中蒽醌类药物含量的准确测定.
기우은곤류약물재감성조건하대고전산갑-로미낙화학발광체계적화학발광신호유강렬적억제작용저일현상,결합류동주사기술건립료일충직접측정은곤류약물적류동주사화학발광분석신방법.해방법측정대황소적선성범위위1.0×10~(-8)-3.0×10~(-7)g/mL,검출한위2×10~(-9)g/mL,측정대황산적선성범위위7.0×10~(-8)-3.0×10~(-6)g/mL,검출한위2×10~(-8)g/mL;측정대황소갑미적선성범위위1.0×10~(-9)-5.0×10~(-8)g/mL,검출한위3×10~(-10)g/mL.해방법조작간단쾌속、령민도고,가용우양품중은곤류약물함량적준학측정.
A new method for the determination of emodin,rhein and emodin methyl ether was developed.The linear range for emodin is in 1.0×10~(-8)-3.0×10~(-7)g/mL,and the detection limit (3σ)for emodin is 2×10~(-9)g/mL.The relative chemiluminescence intensity is proportional to rhein concentration in the range of 7.0×10~(-8)-3.0×10~(-6)g/mL with the detection limit(3σ)of 2×10~(-8) g/mL.The linear range for emodin methyl ether is in 5.0×10~(-9)-5.0×10~(-8)g/mL,and the detection limit(3)for emodin methyl ether is 3×10~(-10)g/mL.