CAJ | 학술논문

以十二烷基二甲基叔胺、环氧氯丙烷、月桂酸为原料,经两步反应合成了一种新型含酯基季铵盐杀菌剂(2-羟基-3-月桂酰氧基丙基)十二烷基二甲基氯化铵(HFAC).第一步的最佳合成条件为:n(环氧氯丙烷):n(十二烷基二甲基叔胺)=1.2、反应温度25 ℃、反应时间4 h,此时中间体十二烷基-(2,3-环氧丙基)二甲基氯化铵(HYAC)的收率为82.54%.第二步的最佳合成条件为:n(月桂酸):n(HYAC)=1.2、反应温度60 ℃、反应时间6 h,此时目标产物HFAC的收率为92.58%.用傅里叶变换红外光谱、元素分析、氢核磁共振和飞行时间质谱对中间体和产物进行了结构表征.同时将HFAC用于处理造纸污水,当污水中HFAC的质量分数为0.010%、杀菌时间为18 h时,HFAC能达到很好的杀菌效果.
이십이완기이갑기숙알、배양록병완、월계산위원료,경량보반응합성료일충신형함지기계안염살균제(2-간기-3-월계선양기병기)십이완기이갑기록화안(HFAC).제일보적최가합성조건위:n(배양록병완):n(십이완기이갑기숙알)=1.2、반응온도25 ℃、반응시간4 h,차시중간체십이완기-(2,3-배양병기)이갑기록화안(HYAC)적수솔위82.54%.제이보적최가합성조건위:n(월계산):n(HYAC)=1.2、반응온도60 ℃、반응시간6 h,차시목표산물HFAC적수솔위92.58%.용부리협변환홍외광보、원소분석、경핵자공진화비행시간질보대중간체화산물진행료결구표정.동시장HFAC용우처리조지오수,당오수중HFAC적질량분수위0.010%、살균시간위18 h시,HFAC능체도흔호적살균효과.
A novel quaternary ammonium salt bactericide containing ester structure (2 hydroxy 3 lauryl acyloxypropyl) dodecyl dimethyl ammonium chloride (HFAC) was prepared from N,N dimethyl dodecylamine, epichlorohydrin and lauric acid by two step synthesis. The intermediate dodecyl (2,3 epoxypropyl) dimethyl ammonium chloride(HYAC)was first prepared from N,N dimethyl dodecylamine and epichlorohydrin by nucleophilic substitution reaction. Under the optimized reaction conditions for HYAC synthesis: n(epichlorohydrin):n(N,N dimethyl dodecylamine) 1.2, reaction time 4 h and reaction temperature 25 ℃, the yield of HYAC was 82.54%. The target product HFAC was obtained by reacting the intermediate HYAC with lauric acid. Under the optimized reaction conditions for HFAC synthesis: n(lauric acid):n(HYAC) 1.2, reaction time 6 h and reaction temperature 60 ℃, the yield of HFAC was 92.58%. Both the intermediate and the target product were characterized by means of FTIR, EA, ~1H NMR, TOF MS, etc.. The HFAC had been applied in treatment of paper making wastewater and had promising sterilization property under appropriate conditions: HFAC mass fraction (based on mass of the wastewater) 0.010% and sterilizing time 18 h.