CAJ | 학술논문

目的:探讨精神分裂症患者合并糖尿病对认知功能的影响.方法:对78例合并糖尿病的精神分裂症患者与118例无糖尿病也无糖耐量异常的精神分裂症患者采用阳性与阴性症状量表及5个认知功能量表评定临床症状与认知功能.结果:与不伴糖尿病的精神分裂症患者相比,伴糖尿病的精神分裂症患者处理速度、注意/工作记忆、执行功能和视觉记忆功能受损严重(P＜0.05).数字符号测验、连线测验A和B成绩与糖尿病病程与起病年龄相关联(P＜0.01).结论:精神分裂症伴发糖尿病者较不伴糖尿病者存在更严重的认知功能损害,提示治疗精神分裂症患者合并糖尿病可能有助于其认知功能的改善.
목적:탐토정신분렬증환자합병당뇨병대인지공능적영향.방법:대78례합병당뇨병적정신분렬증환자여118례무당뇨병야무당내량이상적정신분렬증환자채용양성여음성증상량표급5개인지공능량표평정림상증상여인지공능.결과:여불반당뇨병적정신분렬증환자상비,반당뇨병적정신분렬증환자처리속도、주의/공작기억、집행공능화시각기억공능수손엄중(P＜0.05).수자부호측험、련선측험A화B성적여당뇨병병정여기병년령상관련(P＜0.01).결론:정신분렬증반발당뇨병자교불반당뇨병자존재경엄중적인지공능손해,제시치료정신분렬증환자합병당뇨병가능유조우기인지공능적개선.
Objective To determine the influence of schizophrenia patients with diabetes on cognitive function.Methods Altogether 78 schizophrenia patients with diabetes and 118 patients with schizophrenia were enrolled and Negative and Positive Syndrome Scale,Wechsler Memory Scale-Revised Visual Reproduction Test,Wechsler Adult Intelligence Scale-Revised Digit Symbol Test,Computerized Wisconsin Card Sorting Test,Trail Making Tests,Part A and B,and Wechsler Adult Intelligence Scale-Revised Digit Span Test were used to assess the clinical syndrome and to test the cognitive function.Results Impairment of Processing Speed,Attention/Working Memory,Executive Functioning and Visual Memory in schizophrenia patients with diabetes was significantly poorer than that of the schizophrenia patients ( all P ＜ 0.05 ).WAIS-R Digit Symbol Test score and Trail Making Test A and B scores were associated with diabetes duration and age at diabetes onset (P ＜0.01 ).Conclusion The impairment of cognitive function in schizophrenia patients with diabetes is severer than schizophrenia patients,suggesting that the prevention and management of diabetes may improve cognitive outcome in schizophrenia patients.