中国化学快报（英文版）
中國化學快報（英文版）
중국화학쾌보（영문판）
CHINESE CHEMICAL LETTERS
2012年
4期
466-469
,共4页
Sreekanth Thota%Mohammad Imran%Manasa Udugula%Rajeshwar Yerra%Subhas S. Karki%Jan Balzarini%Erik De Clercq
Sreekanth Thota%Mohammad Imran%Manasa Udugula%Rajeshwar Yerra%Subhas S. Karki%Jan Balzarini%Erik De Clercq
Sreekanth Thota%Mohammad Imran%Manasa Udugula%Rajeshwar Yerra%Subhas S. Karki%Jan Balzarini%Erik De Clercq
Ruthenium complexes%Leukemia cells%MTT assay
The synthesis and spectroscopic characterization of ruthenium complexes (R-1 to R-8) of the type [Ru(A)2(B)],(where A =1,10-phenanthroline/2,2'-bipyridine and B =3,4,5-tri-OCH3-DPC,4-CH3-DPC,4-N-(CH3)2-DPC,4-NO2-DPC are described.These ligands form bidentate octahedral ruthenium complexes.The title complexes were subjected to in vitro cytotoxic activity measurements against the human cancer T-lymphocyte cell lines MTT assay.In vitro evaluation of these ruthenium complexes revealed cytotoxic activity from 0.24 to 1.4 μg/mL against CEM,0.44 to 1.9 μg/mL against Molt4/C8,0.28 to 1.5 μg/mL against L1210,0.24 to 0.98 μg/mL against HL60,and 0.25 to 1.2 μg/mL against BEL7402,depending the nature of the compound.
