CAJ | 학술논문

骨桥蛋白是一种表达于多种组织和细胞的糖蛋白,通过翻译后修饰而在细胞内外存在多种活性形式,可结合不同的受体发生信号转导,介导细胞黏附和迁移、肿瘤侵袭及抗凋亡作用,参与包括Th17在内的Th细胞系的调节.骨桥蛋白能加强机体对分枝杆菌和病毒抗感染能力,且在自身免疫病、银屑病中大量表达,能影响速发性和迟发性变态反应引起的炎症和肉芽肿形成.对骨桥蛋白进行深入研究将为人们治疗相关皮肤病带来新的手段.
골교단백시일충표체우다충조직화세포적당단백,통과번역후수식이재세포내외존재다충활성형식,가결합불동적수체발생신호전도,개도세포점부화천이、종류침습급항조망작용,삼여포괄Th17재내적Th세포계적조절.골교단백능가강궤체대분지간균화병독항감염능력,차재자신면역병、은설병중대량표체,능영향속발성화지발성변태반응인기적염증화육아종형성.대골교단백진행심입연구장위인문치료상관피부병대래신적수단.
Osteopontin (OPN), a glycoprotein expressed by various tissues and cells, has multiple variant forms following post-translational modification, which may explain its broad range of functions. Through interaction with different receptors, OPN can mediate cell adhesion, migration, tumor invasion and antiapoptotic effects, and participate in the regulation of T helper cell lineages (including Th17 cells). In cutaneous infection, OPN enhances immune responses against Mycobacteria and viruses. Secreted or overexpressed in autoimmune diseases and psoriasis, OPN also affects inflammation and granuloma formation caused by immediate and delayed hypersensitivity reaction. In-depth research on OPN may provide new therapeutic approaches to skin diseases.