CAJ | 학술논문

目的探讨中性粒细胞碱性磷酸酶在系统性红斑狼疮诊断中的价值.方法采用AS-BI法对30例初诊的SLE患者(SLE组)及30例体检健康女性(对照组)外周血涂片进行NAP染色,观察NAP阳性率及阳性积分.结果 SLE患者阳性率、阳性积分分别为(22.1±8.8)%、(22.2±8.9)分;健康对照组阳性率、阳性积分分别为(56.8±9.4)%、(58.2±9.8)分,两者比较差异有统计学意义(P＜0.01).结论 NAP检测对初诊的SLE患者有一定的诊断价值;其在SLE中活性降低的机制尚待进一步探讨.
목적 탐토중성립세포감성린산매재계통성홍반랑창진단중적개치.방법 채용AS-BI법대30례초진적SLE환자(SLE조)급30례체검건강녀성(대조조)외주혈도편진행NAP염색,관찰NAP양성솔급양성적분.결과 SLE환자양성솔、양성적분분별위(22.1±8.8)%、(22.2±8.9)분;건강대조조양성솔、양성적분분별위(56.8±9.4)%、(58.2±9.8)분,량자비교차이유통계학의의(P＜0.01).결론 NAP검측대초진적SLE환자유일정적진단개치;기재SLE중활성강저적궤제상대진일보탐토.
Objective To explore the diagnostic value of NAP activity detection in SLE.Methods Technique of AS-BI was used to NAP staining of peripheral blood smear in patients with newly-diagnosed SLE(30 cases)and normal healthy women(30 cases),to observe positive rate and positive score of NAP.Results The positive rate was(22.1±8.8)% in group SLE,(56.8±9.4)% in group normal;The positive score was(22.2±8.9)in group SLE,(58.2±9.8)in group normal.The positive rate and positive score were much lower in patients with SLE comparing with those in group normal.Differences were statistically significant(P＜0.01).Conclusions The detection of NAP is useful in the patients with newly-diagnosed SLE,but we must go on researching the pathogenesis of NAP activity decreased in SLE.