CAJ | 학술논문

目的探讨血同型半胱氨酸(HCY)水平与颈动脉斑块的关系.方法 2010年6月至2011年6月在健康体检职工中随机分层抽取5852人作为观察对象,进行统一血液生化及颈动脉超声检查,5440人符合入选标准,最后有5377人纳入统计分析,并对颈动脉斑块的相关危险因素进行多因素logistic回归分析.结果 (1)5377(男性3215,女性2162)名观察对象平均年龄(55.18±11.78)岁.将观察对象按HCY水平的三分位数分成3组,第一分位数组(＜11.00μmol/L)1771人、第二分位数组(11.00～ 16.98 μmol/L)1814人、第三分位数组(≥16.98 μmol/L)1792人,有颈动脉斑块者2300例；(2)3组研究人群颈动脉斑块现患率分别为29.9％、43.3％和55.0％,组间比较差异有统计学意义(P＜0.05)；(3)影响颈动脉斑块的logistic回归分析:校正其他因素后第三分位数组HCY仍为颈动脉斑块的危险因素,OR=1.344(95％CI:1.134～1.594).结论高HCY与颈动脉斑块的现患率增加有关,是颈动脉斑块的危险因素.
목적 탐토혈동형반광안산(HCY)수평여경동맥반괴적관계.방법 2010년6월지2011년6월재건강체검직공중수궤분층추취5852인작위관찰대상,진행통일혈액생화급경동맥초성검사,5440인부합입선표준,최후유5377인납입통계분석,병대경동맥반괴적상관위험인소진행다인소logistic회귀분석.결과 (1)5377(남성3215,녀성2162)명관찰대상평균년령(55.18±11.78)세.장관찰대상안HCY수평적삼분위수분성3조,제일분위수조(＜11.00μmol/L)1771인、제이분위수조(11.00～ 16.98 μmol/L)1814인、제삼분위수조(≥16.98 μmol/L)1792인,유경동맥반괴자2300례；(2)3조연구인군경동맥반괴현환솔분별위29.9％、43.3％화55.0％,조간비교차이유통계학의의(P＜0.05)；(3)영향경동맥반괴적logistic회귀분석:교정기타인소후제삼분위수조HCY잉위경동맥반괴적위험인소,OR=1.344(95％CI:1.134～1.594).결론 고HCY여경동맥반괴적현환솔증가유관,시경동맥반괴적위험인소.
Objective To explore the relation between homocysteinemia (HCY) and carotid artery plaque.Methods Subjects were derived from a cohort of Kailuan study,which was a community-based and cross-sectional.From June 2010 to June 2011,a total of 5852 subjects were selected from 101 510 working or retired employees at the Tangshan Kailuan Company in 2006-2007.Data was extracted from the results of health examination on the employees.Selecting process was carried out by those staff working on the clinical trials on stroke and from the research center of Tiantan Hospital,Capital Medical University.Subjects who were beyond 40 years of age but without histories as previous stroke,transient ischemic attack (TIA) or myocardial infarction were included and identified,to take part in the study through stratified random sampling.Finally,5440 eligible subjects were enrolled and data from 5377 subjects were analyzed.All the information was obtained through unified questionnaire,blood tests and carotid artery ultrasonography.Multivariate logistic regression was used to analyze the factors related to carotid artery plagues.Results ( 1 )The baseline results showed that the average age of the subjects (n=5377) was 55.18± 11.78 years old with 3215 as males.All the subjects were divided into three groups by tertbiles of HCY,with 1771 subjects in the first quantile group ( HCY ＜ 1 1.00 μmol/L ),1814 in the second quantile group ( 11.00-16.98 μmol/L)and 1792 in the third quantile group( ≥ 16.98 μmol/L).2300 subjects were identified as having carotid artery plaques.(2)The prevalence rates of carotid artery plaques in the three groups were 29.9％,43.3％ and 55.0％ respectively.(3) Afar multivariable adjustment,the third quantile HCY was still serving as a risk factor,affecting the formation of carotid artery plaques,with the OR values as 1.344 (95％CI:1.134-1.594).Conclusion High HCY was related to the increased prevalence of carotid artery plaque and thus served as a risk factor for carotid artery plaque.