国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2011年
6期
476-480
,共5页
钙黏着糖蛋白类%内皮,血管%连环蛋白%毛细血管通透性%新生血管化,生理性%动脉粥样硬化
鈣黏著糖蛋白類%內皮,血管%連環蛋白%毛細血管通透性%新生血管化,生理性%動脈粥樣硬化
개점착당단백류%내피,혈관%련배단백%모세혈관통투성%신생혈관화,생이성%동맥죽양경화
Cadherins%Endothelium,vascular%Catenins%Capillary permeability%Neovascularization,physiologic%Atherosclerosis
血管内皮钙黏蛋白(vascular endothelial cadherin,VE-cadherin)是血管内皮细胞表面特异性表达的一种跨膜黏附蛋白,介导相邻内皮细胞之间的黏附,在保持血管完整性、调节内皮细胞间通透性、白细胞外渗以及细胞内信号转导中发挥着重要作用.除黏附特性外,VE-cadherin还参与调节各种细胞内进程,如细胞增殖、细胞凋亡以及调节血管内皮生长因子受体的功能.因此,VE-cadherin为胚胎发育时血管发生和出生后血管新生所必需,并通过参与血管发生在动脉粥样硬化进程的多个环节发挥着重要作用.
血管內皮鈣黏蛋白(vascular endothelial cadherin,VE-cadherin)是血管內皮細胞錶麵特異性錶達的一種跨膜黏附蛋白,介導相鄰內皮細胞之間的黏附,在保持血管完整性、調節內皮細胞間通透性、白細胞外滲以及細胞內信號轉導中髮揮著重要作用.除黏附特性外,VE-cadherin還參與調節各種細胞內進程,如細胞增殖、細胞凋亡以及調節血管內皮生長因子受體的功能.因此,VE-cadherin為胚胎髮育時血管髮生和齣生後血管新生所必需,併通過參與血管髮生在動脈粥樣硬化進程的多箇環節髮揮著重要作用.
혈관내피개점단백(vascular endothelial cadherin,VE-cadherin)시혈관내피세포표면특이성표체적일충과막점부단백,개도상린내피세포지간적점부,재보지혈관완정성、조절내피세포간통투성、백세포외삼이급세포내신호전도중발휘착중요작용.제점부특성외,VE-cadherin환삼여조절각충세포내진정,여세포증식、세포조망이급조절혈관내피생장인자수체적공능.인차,VE-cadherin위배태발육시혈관발생화출생후혈관신생소필수,병통과삼여혈관발생재동맥죽양경화진정적다개배절발휘착중요작용.
Vascular endothelial cadherin (VE-cadherin) is a transmembrane adhesion protein of specific expression on vascular endothelial cell surface. It mediates the adhesion between adjacent endothelial cells. It plays important roles in maintaining vascular integrity, regulating permeability between endothelial cells, leukocyte extravasation, and intracellular signal transduction. In addition to its adhesion properties, VE-cadherin also participants in regulating various intracellular processes, such as cell proliferation, apoptosis as well as modulating the function of vascular endothelial growth factor receptor. Consequently, VE-cadherin is essential for angiogenesis and postnatal neovascularization during embryogenesis. It plays important roles by participating in angiogenesis in the processes of atherosclerosis of various aspects.
