中国医药
中國醫藥
중국의약
CHINA MEDICINE
2008年
5期
299-301
,共3页
子宫内膜癌%抑癌基因PTEN
子宮內膜癌%抑癌基因PTEN
자궁내막암%억암기인PTEN
Endometrial cancer%Tumor suppressor gene of phosphatase and tensin homolog deleted on chromosome ten
目的 探讨抑癌基因PTEN在子宫内膜癌发生、发展过程中所起的作用,分析抑癌基因PTEN在子宫内膜癌中与某些临床病理学参数之间的关系.方法 采用链霉抗生物素蛋白-过氧化物酶免疫组织化学法分别检测抑癌基因PTEN蛋白在15例正常子宫内膜、15例子宫内膜癌前病变、40例原发性子宫内膜癌各组织标本中的表达情况.结果 ①抑癌基因PTEN在正常子宫内膜组织中的表达率最高,为93.3%(14/15);在癌前病变组织中表达率有所下降,为66.7%(10/15);而在癌组织中表达率最低,为45.0%(18/40),3者比较有统计学意义(P＜0.05).②抑癌基因PTEN表达与子宫内膜癌的组织学类型有关,腺癌表达率(37.1%)明显低于其他类型子宫内膜癌的表达率(100%),2者相比差异有统计学意义(P＜0.05).③抑癌基因PTEN表达与,临床分期、肌层浸润深度、病理分化程度、淋巴结转移无关(P＞0.05).④本研究对40例子宫内膜癌患者术后情况进行了随访,抑癌基因PTEN阳性表达者的病死率(5.6%)明显低于阴性表达者(40.9%),2者差异有统计学意义(P＜0.05).随访5年以上18例,比较抑癌基因PTEN阳性与阴性表达者的5年生存率,阳性表达者5年生存率(100%)明显高于阴性表达者(50.0%)(P＜0.05).结论 抑癌基因PTEN在子宫内膜癌发生过程中起到重要作用,抑癌基因PTEN失表达与肿瘤的组织学类型有关.抑癌基因PTEN表达与临床分期、肌层浸润深度、病理学分级、淋巴结转移等临床病理学参数之间无明显相关性.抑癌基因PTEN表达与子宫内膜癌患者的预后有关.
目的 探討抑癌基因PTEN在子宮內膜癌髮生、髮展過程中所起的作用,分析抑癌基因PTEN在子宮內膜癌中與某些臨床病理學參數之間的關繫.方法 採用鏈黴抗生物素蛋白-過氧化物酶免疫組織化學法分彆檢測抑癌基因PTEN蛋白在15例正常子宮內膜、15例子宮內膜癌前病變、40例原髮性子宮內膜癌各組織標本中的錶達情況.結果 ①抑癌基因PTEN在正常子宮內膜組織中的錶達率最高,為93.3%(14/15);在癌前病變組織中錶達率有所下降,為66.7%(10/15);而在癌組織中錶達率最低,為45.0%(18/40),3者比較有統計學意義(P＜0.05).②抑癌基因PTEN錶達與子宮內膜癌的組織學類型有關,腺癌錶達率(37.1%)明顯低于其他類型子宮內膜癌的錶達率(100%),2者相比差異有統計學意義(P＜0.05).③抑癌基因PTEN錶達與,臨床分期、肌層浸潤深度、病理分化程度、淋巴結轉移無關(P＞0.05).④本研究對40例子宮內膜癌患者術後情況進行瞭隨訪,抑癌基因PTEN暘性錶達者的病死率(5.6%)明顯低于陰性錶達者(40.9%),2者差異有統計學意義(P＜0.05).隨訪5年以上18例,比較抑癌基因PTEN暘性與陰性錶達者的5年生存率,暘性錶達者5年生存率(100%)明顯高于陰性錶達者(50.0%)(P＜0.05).結論 抑癌基因PTEN在子宮內膜癌髮生過程中起到重要作用,抑癌基因PTEN失錶達與腫瘤的組織學類型有關.抑癌基因PTEN錶達與臨床分期、肌層浸潤深度、病理學分級、淋巴結轉移等臨床病理學參數之間無明顯相關性.抑癌基因PTEN錶達與子宮內膜癌患者的預後有關.
목적 탐토억암기인PTEN재자궁내막암발생、발전과정중소기적작용,분석억암기인PTEN재자궁내막암중여모사림상병이학삼수지간적관계.방법 채용련매항생물소단백-과양화물매면역조직화학법분별검측억암기인PTEN단백재15례정상자궁내막、15례자궁내막암전병변、40례원발성자궁내막암각조직표본중적표체정황.결과 ①억암기인PTEN재정상자궁내막조직중적표체솔최고,위93.3%(14/15);재암전병변조직중표체솔유소하강,위66.7%(10/15);이재암조직중표체솔최저,위45.0%(18/40),3자비교유통계학의의(P＜0.05).②억암기인PTEN표체여자궁내막암적조직학류형유관,선암표체솔(37.1%)명현저우기타류형자궁내막암적표체솔(100%),2자상비차이유통계학의의(P＜0.05).③억암기인PTEN표체여,림상분기、기층침윤심도、병리분화정도、림파결전이무관(P＞0.05).④본연구대40례자궁내막암환자술후정황진행료수방,억암기인PTEN양성표체자적병사솔(5.6%)명현저우음성표체자(40.9%),2자차이유통계학의의(P＜0.05).수방5년이상18례,비교억암기인PTEN양성여음성표체자적5년생존솔,양성표체자5년생존솔(100%)명현고우음성표체자(50.0%)(P＜0.05).결론 억암기인PTEN재자궁내막암발생과정중기도중요작용,억암기인PTEN실표체여종류적조직학류형유관.억암기인PTEN표체여림상분기、기층침윤심도、병이학분급、림파결전이등림상병이학삼수지간무명현상관성.억암기인PTEN표체여자궁내막암환자적예후유관.
Objective To discuss the role of PTEN in the carcinogenesis and development of ndometrial cancers (EC).and to observe the correlation between PTEN protein expression and the clinical or pathological features in EC.Methods PTEN protein expression was detected in 15 normal human endometrium tissues.15 preeancer tissues and 40 primary EC tissues respectively by immuno histochemical method(SP method).Results PTEN protein expression were found in 14 of 15(93.3%)normal endometrium,10 0f 15(66.7%) precancers and 18 of 40 (45.0%) EC.The difference of PTEN protein concentration among the three groups was statistically significant(P＜0.05).PTEN protein expression varies according to tumors types.The expression in endometrial adenocarcinomas (37.1%) was much lower than in other types of EC (P＜0.05).In contrast,no significant differences of PTEN protein expression were observed in FIGO stage,pathologic grade,myometrial invasion and lymph node metastatic.All 40 EC patients were followed up after operation.10 patients of them died.The mortality in PTEN positive stain (5.6%) was significant lower than in PTEN negative stain(40.9%)(P＜0.05).Conclusion The PTEN protein expression in different endometrium tissues iS important for the pathogenesis of ECs,and the loss of PTEN function due to the mutational or other mechanisms iS possibly the earliest event in the pathogenesis of endometrial adenocarcinoma.Moreover.PTEN expression iS related to the prognosis of EC.
