CAJ | 학술논문

目的研究125I放射性粒子组织间植入对于食管癌移植瘤的影响.方法将人食管癌细胞Eca-109注入裸鼠腋侧皮下建立食管癌裸鼠移植瘤模型,随机分成对照组(牛理盐水+空心粒子)、125I粒子组(剂量22.2 MBq×1)和顺铂组(1 ms/kg).观察人食管癌移植瘤的生长情况和病理学改变.结果术后16 d,对照组、125I粒了组、顺铂组的瘤块平均重量分别为(0.20±0.06)g,(0.12±0.03)g,(0.12±0.05)g,3组间差异有统计学意义(P<0.05).病理结果,125I粒子组、顺铂组镜下可见变性、坏死的食管癌肿瘤细胞.125I粒子组、顺铂组肿瘤组织坏死范围大于对照组(P<0.05).结论 125I粒子植入可以引起食管癌移植瘤肿瘤组织变性、坏死,抑制肿瘤组织的生长.
목적 연구125I방사성입자조직간식입대우식관암이식류적영향.방법 장인식관암세포Eca-109주입라서액측피하건립식관암라서이식류모형,수궤분성대조조(우리염수+공심입자)、125I입자조(제량22.2 MBq×1)화순박조(1 ms/kg).관찰인식관암이식류적생장정황화병이학개변.결과 술후16 d,대조조、125I립료조、순박조적류괴평균중량분별위(0.20±0.06)g,(0.12±0.03)g,(0.12±0.05)g,3조간차이유통계학의의(P<0.05).병리결과,125I입자조、순박조경하가견변성、배사적식관암종류세포.125I입자조、순박조종류조직배사범위대우대조조(P<0.05).결론 125I입자식입가이인기식관암이식류종류조직변성、배사,억제종류조직적생장.
Objective To investigate the effect of interstitial brachytherapy with 125Ⅰon human esophageal carcinoma implanted in nude mice. Methods Animal model simulating human esophageal carcinoma was established by subcutaneous implantation of cultured Eca-109 cell lines into nude mice.The mice were randomly divided into 3 groups,namely control group (saline plus empty seed),125Ⅰ seed group (22.2 MBq×1 seed),and DDP group (cisplatin at the dose of 1 mg/kg),to receive corresponding treatment.The growth rate and the pathological changes of esophageal carcinoma were observed.Results The animals were sacrificed 16 days after irradiation.The average tumor weight in control group,125Ⅰ seed group,and DDP group were (0.20±0.06) g, (0.12±0.03) g and (0.12±0.05 ) g,respectively (P<0.05).Pathological findings included degeneration and necrosis of the tumor cells.Compared to the control group,the necrosis areas in 125Ⅰ seed group and DDP group were significantly larger than those in control (P<0.05).Conclusion 125Ⅰ seed brachytherapy in esophageal carcinoma could cause degeneration and necrosis of the tumor cells and had inhibitory effect on tumor growth.