中华整形外科杂志
中華整形外科雜誌
중화정형외과잡지
CHINESE JOURNAL OF PLASTIC SURGERY
2011年
3期
178-181
,共4页
宋佳%欧阳天祥%黄莹滢%刘军%肖燕%陈惠平%虞杰
宋佳%歐暘天祥%黃瑩瀅%劉軍%肖燕%陳惠平%虞傑
송가%구양천상%황형형%류군%초연%진혜평%우걸
不消退型先天性血管瘤%婴幼儿血管瘤%葡萄糖转运蛋白-1%病理学
不消退型先天性血管瘤%嬰幼兒血管瘤%葡萄糖轉運蛋白-1%病理學
불소퇴형선천성혈관류%영유인혈관류%포도당전운단백-1%병이학
Noninvoluting congenital hemangioma%Infantile hemangioma%Glucose transport protein-1%Pathology
目的 比较研究不消退型先天性血管瘤(noninvoluting congenital hemangioma,NICH)与婴幼儿血管瘤(infantile hemangioma,IH)的病理特征,检测葡萄糖转运蛋白-1(Glut-1)的表达,探讨NICH的病理结构与病程发展的关系.方法 2005年1月至2010年8月,收集13例NICH,13例增殖期IH和13例消退期IH临床标本,采用HE染色和免疫组化染色方法,比较NICH、增殖期IH和消退期IH的病理结构以及Glut-1的表达.结果 HE染色显示,NICH瘤体呈规则的小叶结构,小叶被丰富的纤维组织包绕,小叶内微血管管径较大,小叶内血管壁完整,内皮细胞罕有增殖和凋亡.IH病变呈现从增殖到消退改变,微血管管径较小,血管壁不完整,周细胞扁平,血管内皮细胞和间质细胞可见增殖和凋亡.NICH中不表达Glut-1,增殖期IH肿瘤内皮细胞中Glut-1表达阳性,消退期IH中Glut-1表达阴性或弱阳性.结论 NICH是一种具有低增殖性的血管瘤,病理结构稳定,与增生期IH血管内皮细胞的增殖性具有明显的不同;Glut-1可以作为鉴别NICH和增殖期IH的可靠抗原标记.
目的 比較研究不消退型先天性血管瘤(noninvoluting congenital hemangioma,NICH)與嬰幼兒血管瘤(infantile hemangioma,IH)的病理特徵,檢測葡萄糖轉運蛋白-1(Glut-1)的錶達,探討NICH的病理結構與病程髮展的關繫.方法 2005年1月至2010年8月,收集13例NICH,13例增殖期IH和13例消退期IH臨床標本,採用HE染色和免疫組化染色方法,比較NICH、增殖期IH和消退期IH的病理結構以及Glut-1的錶達.結果 HE染色顯示,NICH瘤體呈規則的小葉結構,小葉被豐富的纖維組織包繞,小葉內微血管管徑較大,小葉內血管壁完整,內皮細胞罕有增殖和凋亡.IH病變呈現從增殖到消退改變,微血管管徑較小,血管壁不完整,週細胞扁平,血管內皮細胞和間質細胞可見增殖和凋亡.NICH中不錶達Glut-1,增殖期IH腫瘤內皮細胞中Glut-1錶達暘性,消退期IH中Glut-1錶達陰性或弱暘性.結論 NICH是一種具有低增殖性的血管瘤,病理結構穩定,與增生期IH血管內皮細胞的增殖性具有明顯的不同;Glut-1可以作為鑒彆NICH和增殖期IH的可靠抗原標記.
목적 비교연구불소퇴형선천성혈관류(noninvoluting congenital hemangioma,NICH)여영유인혈관류(infantile hemangioma,IH)적병리특정,검측포도당전운단백-1(Glut-1)적표체,탐토NICH적병리결구여병정발전적관계.방법 2005년1월지2010년8월,수집13례NICH,13례증식기IH화13례소퇴기IH림상표본,채용HE염색화면역조화염색방법,비교NICH、증식기IH화소퇴기IH적병리결구이급Glut-1적표체.결과 HE염색현시,NICH류체정규칙적소협결구,소협피봉부적섬유조직포요,소협내미혈관관경교대,소협내혈관벽완정,내피세포한유증식화조망.IH병변정현종증식도소퇴개변,미혈관관경교소,혈관벽불완정,주세포편평,혈관내피세포화간질세포가견증식화조망.NICH중불표체Glut-1,증식기IH종류내피세포중Glut-1표체양성,소퇴기IH중Glut-1표체음성혹약양성.결론 NICH시일충구유저증식성적혈관류,병리결구은정,여증생기IH혈관내피세포적증식성구유명현적불동;Glut-1가이작위감별NICH화증식기IH적가고항원표기.
Objective To distinguish noninvoluting congenital hemangioma (NICH) and infantile hemangioma ( IH ) by comparing the pathological structure and marker antigen expression. Methods From Jan. 2005 to Aug. 2010,39 paraffin-embedded samples, including 13 cases of NICH, 13 cases of proliferating IH and 13 cases of involuting IH, were collected from operation. Hematoxylin-eosin staining was used to observe the pathological structure. Immunohistochemical analysis was also performed to investigate the expression of Glut-1. Results The lobules of capillaries were well-defined in NICH. The lobules were surrounded by abundant fibrous tissue. The capillaries were often large and integrity in NICH.There were few mitosis and apoptosis in endothelial cells and stromal cells in NICH. While in IH, the pathologic findings were totally different. Immunochemistry revealed that the Glut-1 was expressed in endothelial cells of IH, but not in NICH. Conclusions NICH has a steady histologic structure and low proliferation, while the endothelial cells in proliferative IH has a high proliferation. Glut-1 can be used as the reliable marker antigen for differential diagnosis of NICH and proliferative infantile hemangiomas.
