中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2004年
14期
2748-2749
,共2页
汪建%熊敏%何青莲%尤景敏%邓恒山
汪建%熊敏%何青蓮%尤景敏%鄧恆山
왕건%웅민%하청련%우경민%산항산
血管内皮生长因子%鼻息肉%免疫组织化学
血管內皮生長因子%鼻息肉%免疫組織化學
혈관내피생장인자%비식육%면역조직화학
背景:有大量的文献表明血管内皮生长因子在肿瘤的形成中起重要作用,但少有文献探讨血管内皮生长因子在鼻息肉形成中的作用.目的:探讨血管内皮生长因子及其受体在鼻腔生理及鼻息肉形成中的作用.设计:以诊断为依据设立对照的实验研究.地点和对象:实验在解放军广州军区广州总医院耳鼻咽喉科完成,对象为鼻息肉患者30例,均来自本院耳鼻喉科住院手术患者.6名志愿者为本科因非鼻息肉住院的患者.主要观察指标:鼻息肉组织和正常鼻黏膜组织血管内皮生长因子及其受体的表达.结果:血管内皮生长因子及其受体在正常鼻黏膜中呈阳性表达,在鼻息肉组织中呈强阳性表达.结论:本实验结果提示血管内皮生长因子及其受体参与正常鼻腔生理功能的调节,并参与鼻息肉的形成机制.因而推测鼻息肉术后在鼻腔应用血管内皮生长因子的拮抗剂对鼻息肉的复发有预防作用.
揹景:有大量的文獻錶明血管內皮生長因子在腫瘤的形成中起重要作用,但少有文獻探討血管內皮生長因子在鼻息肉形成中的作用.目的:探討血管內皮生長因子及其受體在鼻腔生理及鼻息肉形成中的作用.設計:以診斷為依據設立對照的實驗研究.地點和對象:實驗在解放軍廣州軍區廣州總醫院耳鼻嚥喉科完成,對象為鼻息肉患者30例,均來自本院耳鼻喉科住院手術患者.6名誌願者為本科因非鼻息肉住院的患者.主要觀察指標:鼻息肉組織和正常鼻黏膜組織血管內皮生長因子及其受體的錶達.結果:血管內皮生長因子及其受體在正常鼻黏膜中呈暘性錶達,在鼻息肉組織中呈彊暘性錶達.結論:本實驗結果提示血管內皮生長因子及其受體參與正常鼻腔生理功能的調節,併參與鼻息肉的形成機製.因而推測鼻息肉術後在鼻腔應用血管內皮生長因子的拮抗劑對鼻息肉的複髮有預防作用.
배경:유대량적문헌표명혈관내피생장인자재종류적형성중기중요작용,단소유문헌탐토혈관내피생장인자재비식육형성중적작용.목적:탐토혈관내피생장인자급기수체재비강생리급비식육형성중적작용.설계:이진단위의거설립대조적실험연구.지점화대상:실험재해방군엄주군구엄주총의원이비인후과완성,대상위비식육환자30례,균래자본원이비후과주원수술환자.6명지원자위본과인비비식육주원적환자.주요관찰지표:비식육조직화정상비점막조직혈관내피생장인자급기수체적표체.결과:혈관내피생장인자급기수체재정상비점막중정양성표체,재비식육조직중정강양성표체.결론:본실험결과제시혈관내피생장인자급기수체삼여정상비강생리공능적조절,병삼여비식육적형성궤제.인이추측비식육술후재비강응용혈관내피생장인자적길항제대비식육적복발유예방작용.
BACKGROUND: A large amount of references suggest that vascular endothelial growth factor(VEGF) plays an important role in tumor formation,but there are now few references about the functions of VEGF in the formation of rhinopolypus.OBJECTIVE: To investigate the functions of VEGF and its receptors in nasal physiology and in formation of rhinopolypus.DESIGN: A control experimental study depended on diagnosis was conducted.SETTING and PARTICIPANTS: The experiment was completed in the Department of Otorhinolaryngology, Guangzhou General Hospital of Guangzhou Military Region. The subjects were 30 patients with rhinopolypus who were in-patients operated in the department of othorhinolaryngology. 6volunteers were also in-patients with non-rhinopolypus.MAIN OUTCOME MEASURES: The expression of VEGF and its receptors in polypous tissue and in normal nasal mucosa tissues.RESULTS: The expression of VEGF and its receptors was positive in normal nasal mucosa tissues and strong positive in polypous tissue.CONCLUSION: The experiment suggests that VEGF and its receptors can participate in the regulation of normal nasal physiological functions and in the mechanism of formation of rhinopolypus. So it is inferred that the recurrence of rhinopolypus can be prevented by using VEGF antagonists in nasal cavities after nasal polypectomy.