CAJ | 학술논문

目的:研究三阴性乳腺癌的临床病理特点、预后及与EGFR表达的关系.方法:回顾性分析天津医科大学总医院1997年1月至2004年1月200例乳腺癌患者的临床资料,总结其病理特征及随访结果,并将200例病例对应的石蜡标本制作成组织芯片,用免疫组织化学法检测乳腺癌组织中ER、PR、HER-2的表达,进行乳腺癌分子分型.检测EGFR蛋白的表达,分析其与乳腺癌病理特征及预后的关系.结果:200例乳腺癌患者中三阴性乳腺癌42例(21.00%),在患者年龄、肿瘤大小、临床分期、淋巴结状态等病理参数的分析中,三阴性乳腺癌与非三阴性乳腺癌的分布无明显差异,而在绝经状态及肿瘤组织学分级的分析中,三阴性乳腺癌与非三阴性乳腺癌差异有统计学意义(P<0.05).三阴性乳腺癌患者中17例死亡(生存率59.52%),非三阴性患者26例死亡(生存率83.54%),二者有显著性差异(P<0.05).EGFR在三阴性乳腺癌中表达率较高(69.05%),与肿瘤组织学分级及淋巴结转移密切相关,且表达EGFR的三阴性乳腺癌患者生存时间较短.结论:三阴性乳腺癌发病率虽然不高,但其与常规的乳腺癌预后相关因素缺乏特定联系,患者预后差.EGFR在三阴性乳腺癌中高表达,可作为三阴性乳腺癌的一个重要的预后指标,并为临床提供了治疗的靶点.
목적:연구삼음성유선암적림상병리특점、예후급여EGFR표체적관계.방법:회고성분석천진의과대학총의원1997년1월지2004년1월200례유선암환자적림상자료,총결기병리특정급수방결과,병장200례병례대응적석사표본제작성조직심편,용면역조직화학법검측유선암조직중ER、PR、HER-2적표체,진행유선암분자분형.검측EGFR단백적표체,분석기여유선암병리특정급예후적관계.결과:200례유선암환자중삼음성유선암42례(21.00%),재환자년령、종류대소、림상분기、림파결상태등병리삼수적분석중,삼음성유선암여비삼음성유선암적분포무명현차이,이재절경상태급종류조직학분급적분석중,삼음성유선암여비삼음성유선암차이유통계학의의(P<0.05).삼음성유선암환자중17례사망(생존솔59.52%),비삼음성환자26례사망(생존솔83.54%),이자유현저성차이(P<0.05).EGFR재삼음성유선암중표체솔교고(69.05%),여종류조직학분급급림파결전이밀절상관,차표체EGFR적삼음성유선암환자생존시간교단.결론:삼음성유선암발병솔수연불고,단기여상규적유선암예후상관인소결핍특정련계,환자예후차.EGFR재삼음성유선암중고표체,가작위삼음성유선암적일개중요적예후지표,병위림상제공료치료적파점.
Objective:To study the clinicopathologic characteristics and the prognostic factors of triple negative breast cancer,and to study the correlation between clinicopathologic features and EGFR expression.Methods:Clinical characteristics and prognosis of 200 breast cancer patients diagnosed between 1997 and 2004 were reviewed.The paraffin embedded tissues were selected and tissue microarray blocks were made.Immunohistochemical staining was used to evaluate the expression of ER,PR and HER2 for breast cancer molecular type.EGFR expression was evaluated to analyze its correlation with the clinical characteristics and prognosis.Results:Fourty-two cases(21%)of 200 were triple negative breast cancer(TNBC).There was no significant difference between TNBC and non-TNBC in clinicopathologic parameters such as age,tumor size,clinical stage,and lymph node status.However,there was significant difference in histological category and menostasis status between the two groups(P<0.05).Among TNBC,17 0f 42 died during the follow-up(the overall suivival rate was 59.52%),while 26 0f 158 non-TNBC died(the overall survival rate was 83.54%).EGFR was significantly overexpressed in TNBC(69.05%)and it was associated with lymph node status and histological category.Conclusion:Although the incidence of TNBC is low,it has a poorer prognosis than other subtypes.EGFR is highly expressed in TNBC and may serve as a prognostic index and an important therapatic target for breast cancer.