国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2008年
4期
247-249
,共3页
急性脑梗死%通腑醒神口服液
急性腦梗死%通腑醒神口服液
급성뇌경사%통부성신구복액
Tongfu Xingshen Oral Liquid%Cerebral infarction of phlegm-heat accumulated in large intestine and wind-phlegm invading upward type
目的 研究通腑醒神口服液治疗痰热腑实、风痰上扰型脑梗死的临床疗效及对内皮素(ET-1)、肿瘤坏死因子(TNF-α)及血黏度的影响.方法 将60例痰热腑实、风痰上扰型脑梗死患者随机分为通腑醒神口服液治疗组(治疗组)30例和常规治疗组(对照组)30例,加用通腑醒神口服液100ml/次,2次,d,20d为1个疗程.测定两组患者治疗前后血浆ET-1、血清TNF-α,血黏度水平的变化;评价治疗前后28 d的神经功能缺损积分.结果 治疗前,脑梗死患者血浆ET-1、血清TNF-α、全血黏度、血浆黏度、纤维蛋白原(FI)水平明显高于健康组.治疗后,通腑醒神口服液组的总有效率(90%)明显高于常规组(72.5%)(P＜0.05);治疗后两组的血浆ET-1、血清TNF-α、全血黏度值、血浆黏度值、FI水平水平均降低,治疗组更为明显.结论 通腑醒神口服液配合常规治疗可更好地改善症状,促进缺损神经功能康复.
目的 研究通腑醒神口服液治療痰熱腑實、風痰上擾型腦梗死的臨床療效及對內皮素(ET-1)、腫瘤壞死因子(TNF-α)及血黏度的影響.方法 將60例痰熱腑實、風痰上擾型腦梗死患者隨機分為通腑醒神口服液治療組(治療組)30例和常規治療組(對照組)30例,加用通腑醒神口服液100ml/次,2次,d,20d為1箇療程.測定兩組患者治療前後血漿ET-1、血清TNF-α,血黏度水平的變化;評價治療前後28 d的神經功能缺損積分.結果 治療前,腦梗死患者血漿ET-1、血清TNF-α、全血黏度、血漿黏度、纖維蛋白原(FI)水平明顯高于健康組.治療後,通腑醒神口服液組的總有效率(90%)明顯高于常規組(72.5%)(P＜0.05);治療後兩組的血漿ET-1、血清TNF-α、全血黏度值、血漿黏度值、FI水平水平均降低,治療組更為明顯.結論 通腑醒神口服液配閤常規治療可更好地改善癥狀,促進缺損神經功能康複.
목적 연구통부성신구복액치료담열부실、풍담상우형뇌경사적림상료효급대내피소(ET-1)、종류배사인자(TNF-α)급혈점도적영향.방법 장60례담열부실、풍담상우형뇌경사환자수궤분위통부성신구복액치료조(치료조)30례화상규치료조(대조조)30례,가용통부성신구복액100ml/차,2차,d,20d위1개료정.측정량조환자치료전후혈장ET-1、혈청TNF-α,혈점도수평적변화;평개치료전후28 d적신경공능결손적분.결과 치료전,뇌경사환자혈장ET-1、혈청TNF-α、전혈점도、혈장점도、섬유단백원(FI)수평명현고우건강조.치료후,통부성신구복액조적총유효솔(90%)명현고우상규조(72.5%)(P＜0.05);치료후량조적혈장ET-1、혈청TNF-α、전혈점도치、혈장점도치、FI수평수평균강저,치료조경위명현.결론 통부성신구복액배합상규치료가경호지개선증상,촉진결손신경공능강복.
Objective To study the therapeutic effect of Tongfu Xingshen Oral Liquid on the cerebral infarction of phlegm-heat accumulated in large intestime and wind-phlegm invading upward type and the impact of this Oral liquid on plasma ET-1,TNF-α and the blood viscosity.Methods 60 cases of cerebral infarction patients were randomly divided into Tongfu Xingshen Oral Liquid treatment group(n=30)and conventional therapeutic group(n=30).Besides Routine treatment was used in the two groups,the Tongfu Xingshen Oral Liquid,100ml twice dally,was added in the treatment group.The course of treatment for both groups was 20 days.RIA,double-antibody sandwich enzyme-linked immunosorbent assay (ELISA)and LG-R-80A hemorbeology instrument were used to determine the level of all patients'plasma ET-1,serum TNF-α,blood viscosity,before and after the treatment.Meanwhile,neurological impairment scale Was assayed before and 28 days after the treatment.30 healthy people were recruited as controls.Results The plasma ET-1,serum TNF-α,whole blood viscosity value,plasma viscosity value.RBC hardness plot,fibrinogen(FI)levels in cerebral infarction patients were significantly higher than healthy people.The plasma ET-1,serum TNF-α,whole blood viscosity value,plasma viscosity value,RBC hardness plot,fibrinogen(FI)level were positively correlated with the acute cerebral infarction.Thetotal efficiency of the treatment group(90%)was significantly higher than that of the conventional group(72.5%,P＜0.05).The plasma ET-1,serum TNF-α,whole blood viscosity value,Plasma viscosity value,RBC hardness plot,fibrinogen(FD levels were decreased after treatment in the both groups,while the reductions in the treatment group were more obvious than in the conventional therapy group(P＜0.05).Conclusion Tongru Xinshen Oral Liquid can improve the prognosis of cerebral infarction by degrading plasma ET-1,serum TNF-α,whole blood viscosity value,plasma viscosity value,RBC hardness plot,fibrinogen(FI)of acute cerebral infarction patients and degrading cerebrovascular endothelial cells damage,improvingthe clinical symptoms and rehabilitating of neurological defects,.
