中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
8期
1043-1044
,共2页
轮状病毒感染%消旋卡多曲%儿童
輪狀病毒感染%消鏇卡多麯%兒童
륜상병독감염%소선잡다곡%인동
Rotavirus infections%Racecadotril graules%Child
目的 观察消旋卡多曲颗粒辅助治疗儿童轮状病毒肠炎的疗效及不良反应.方法 轮状病毒肠炎患儿100例按数字表法随机分为A组和B组各50例,B组给予常规治疗和蒙脱石散治疗,A组在B组治疗基础上加服消旋卡多曲颗粒,1.5 mg·kg~(-1)·次~(-1),3次/d,疗程5～7 d,观察两组临床治疗效果及不良反应发生情况.结果 A组呕吐改善时间(1.5±0.4)d、退热时间(1.3±0.3)d、腹泻改善时间(1.7±0.4)d较B组的(2.4±0.3)d、(2.3±0.4)d、(2.9±0.1)d明显缩短(t=2.245、2.298、2.301,均P＜0.05);治疗3 d后A组总有效率92.0%,高于B组的(74.0%)(x~2=3.987,P＜0.05);A组平均治愈时间(5.5±0.9)d低于B组的(7.0±1.1)d(t=7.17,P＜0.01);两组均未发生严重不良反应.结论 消旋卡多曲辅助治疗儿童轮状病毒肠炎可提高临床治疗效果,不良反应少.
目的 觀察消鏇卡多麯顆粒輔助治療兒童輪狀病毒腸炎的療效及不良反應.方法 輪狀病毒腸炎患兒100例按數字錶法隨機分為A組和B組各50例,B組給予常規治療和矇脫石散治療,A組在B組治療基礎上加服消鏇卡多麯顆粒,1.5 mg·kg~(-1)·次~(-1),3次/d,療程5～7 d,觀察兩組臨床治療效果及不良反應髮生情況.結果 A組嘔吐改善時間(1.5±0.4)d、退熱時間(1.3±0.3)d、腹瀉改善時間(1.7±0.4)d較B組的(2.4±0.3)d、(2.3±0.4)d、(2.9±0.1)d明顯縮短(t=2.245、2.298、2.301,均P＜0.05);治療3 d後A組總有效率92.0%,高于B組的(74.0%)(x~2=3.987,P＜0.05);A組平均治愈時間(5.5±0.9)d低于B組的(7.0±1.1)d(t=7.17,P＜0.01);兩組均未髮生嚴重不良反應.結論 消鏇卡多麯輔助治療兒童輪狀病毒腸炎可提高臨床治療效果,不良反應少.
목적 관찰소선잡다곡과립보조치료인동륜상병독장염적료효급불량반응.방법 륜상병독장염환인100례안수자표법수궤분위A조화B조각50례,B조급여상규치료화몽탈석산치료,A조재B조치료기출상가복소선잡다곡과립,1.5 mg·kg~(-1)·차~(-1),3차/d,료정5～7 d,관찰량조림상치료효과급불량반응발생정황.결과 A조구토개선시간(1.5±0.4)d、퇴열시간(1.3±0.3)d、복사개선시간(1.7±0.4)d교B조적(2.4±0.3)d、(2.3±0.4)d、(2.9±0.1)d명현축단(t=2.245、2.298、2.301,균P＜0.05);치료3 d후A조총유효솔92.0%,고우B조적(74.0%)(x~2=3.987,P＜0.05);A조평균치유시간(5.5±0.9)d저우B조적(7.0±1.1)d(t=7.17,P＜0.01);량조균미발생엄중불량반응.결론 소선잡다곡보조치료인동륜상병독장염가제고림상치료효과,불량반응소.
Objective To investigate the curative effect of racecadotril granules on acute rotaviral enteritis in infants. Methods 100 infants with acute rotaviral enteritis were divided into combined treatment group(group A:50)cases and smecta group(B group:50 cases) ;Group B was given to basis of conventional therapy,but Group A received conventional therapy combined with clothing racecadotril particles. The efficacy and adverse reactions were observed.Results The time of improvement of vomiting,fever and diarrhea in A group was significantly shorter than the B group(t =2. 245,2. 298,2. 301, all P ＜ 0.05); The total effective rate 92. 0% in A group were higher than the B group 74. 0% after treatment 3d(x~2 = 3.987, P ＜ 0.05). The average course of treatment in A group (5.5 ± 0. 9) d was lower than the B group(7. 0 ± 1.1)d(t =7.17,P＜0.01). Conclusion Racecadotril is an effective and safe drug in treating rotaviral enteritis in infants.
