CAJ | 학술논문

目的探讨离心性环状红斑(EAC)的临床、组织病理、免疫病理变化及其之间的关系.方法临床收集病例,进行性别、年龄、病期、皮疹分布,皮疹形态.症状、伴发疾病等的分析,同时作皮疹的组织病理及直接免疫荧光检查.结果 EAC最常见受累部位为下肢,常伴发多种疾病,以真菌病伴发较多见.病理组织学的基本特征为真皮上部或深部小血管周围的淋巴细胞致密浸润.直接免疫荧光检测的12份标本中,有6例标本的小血管壁显示有IgG、IgM、或C3的沉积.结论 EAC是一种多因素诱发的疾病,皮疹的组织病理及直接免疫荧光检查提示在EAC的发病机制中,淋巴细胞的介导和循环性免疫复合物沉积于真皮小血管壁具有重要的作用.
목적 탐토리심성배상홍반(EAC)적림상、조직병리、면역병리변화급기지간적관계.방법 림상수집병례,진행성별、년령、병기、피진분포,피진형태.증상、반발질병등적분석,동시작피진적조직병리급직접면역형광검사.결과 EAC최상견수루부위위하지,상반발다충질병,이진균병반발교다견.병리조직학적기본특정위진피상부혹심부소혈관주위적림파세포치밀침윤.직접면역형광검측적12빈표본중,유6례표본적소혈관벽현시유IgG、IgM、혹C3적침적.결론 EAC시일충다인소유발적질병,피진적조직병리급직접면역형광검사제시재EAC적발병궤제중,림파세포적개도화순배성면역복합물침적우진피소혈관벽구유중요적작용.
Objective To investigate the clinical, histopathological and immunopathological charac teristics of erythema annulare centrifugum (EAC). Methods A retrospective study was performed on 54 cases of EAC collected from 2001 to 2005. Information was gathered about patients' sex, age, disease course, distribution and morphology of eruptions, symptoms, complications. Also, the findings of histopathology and direct immunofluorescence examination in some patients were evaluated. Remits EAC most commonly occurred on the lower limb, and was usually complicated by various diseases among which mycosis predominated. Histological examination revealed compact lymphocyte infiltration in dermal vessels in 32 of these 54 patients. Direct immunofluorescence showed the deposition of IgG, lgM, or C3 on the walls of small vessels in 6 of 12 tissue samples tested. Conclusions EAC is a multifactorial disease, and it seems that the infiltration of lymphocytes and deposition of circulatory immune complex on small blood vessels in dermis may play important roles in its pathogenesis.