CAJ | 학술논문

目的观察卡泊芬净治疗高龄患者侵袭性真菌病(IFD)的疗效和安全性. 方法回顾分析我院老年病房接受过卡泊芬净治疗的IFD患者的临床资料. 结果 2007年1月至2009年8月共有29例患者接受卡泊芬净治疗,且均为80岁以上高龄患者.除1例于用药当天死亡外,28例可评价疗效的患者中,痊愈13例(46.4%),显效6例(21.4%),进步3例(10.8%),无效6例(21.4%),总有效率为67.8%.13例痊愈者中,12例为念珠菌菌血症患者,1例为拟诊肺白念珠菌病患者.无效6例患者中,2例为念珠菌菌血症患者,1例为拟诊肺念珠菌病患者,3例为疑诊肺IFD患者.治疗过程中1例患者出现谷丙转氨酶升高,考虑为与用药有关的肝功能受损. 结论卡泊芬净是治疗高龄患者侵袭性真菌病的安全有效药物.
목적 관찰잡박분정치료고령환자침습성진균병(IFD)적료효화안전성. 방법 회고분석아원노년병방접수과잡박분정치료적IFD환자적림상자료. 결과 2007년1월지2009년8월공유29례환자접수잡박분정치료,차균위80세이상고령환자.제1례우용약당천사망외,28례가평개료효적환자중,전유13례(46.4%),현효6례(21.4%),진보3례(10.8%),무효6례(21.4%),총유효솔위67.8%.13례전유자중,12례위념주균균혈증환자,1례위의진폐백념주균병환자.무효6례환자중,2례위념주균균혈증환자,1례위의진폐념주균병환자,3례위의진폐IFD환자.치료과정중1례환자출현곡병전안매승고,고필위여용약유관적간공능수손. 결론 잡박분정시치료고령환자침습성진균병적안전유효약물.
Objective To evaluate the efficacy and safety of caspofungin in the treatment of invasive fungal disease (IFD) in advanced age patients. Methods A retrospective analysis of the clinical data was conducted. IFD patients who had received caspofungin treatment in elderly wards were included. Results From January 2007 to August 2009, 29 IFD patients aged 80-100 years (mean 89 ) were treated with caspofungin. Except that one patient dead on the first drug administration day, there were 28 evaluable patients, 13 were cured (46.4%), 6 were markedly improved (21.4%), 3 progressed (10.8%) and 6 dead (21.4%). The overall effective rate was 67. 8%. Of 13cured patients, 12 were Candida bacreremia, 1 was Candida albicans disease of lung. Of 6 dead patients, 2 were Candida bacteremia, 1 was Candida albicans disease of lung and 3 was suspected of lung IFD. One patient performed that alanine aminotransferase was increased, considering drug-related impairment of liver function. Conclusions Caspofungin is effective and safe in the treatment of IFD in advanced age patients.