中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2011年
11期
1127-1129
,共3页
高血压%动态动脉硬化指数%尿白蛋白/肌酐比值%颈动脉内中膜厚度
高血壓%動態動脈硬化指數%尿白蛋白/肌酐比值%頸動脈內中膜厚度
고혈압%동태동맥경화지수%뇨백단백/기항비치%경동맥내중막후도
Hypertension%Ambulatory arterial stiffness index%Urinary albumin and creatinine ratio%Carotid intima-media thickness
目的 研究高血压患者的动态动脉硬化指数(AASI)与肾脏损害以及颈动脉内膜损伤的相关性.方法 筛选无糖尿病和其他致动脉硬化疾病的高血压患者149例,以及同期健康体检者48名作为正常对照组,分别行24h动态血压监测(ABPM)及尿白蛋白及尿肌酐测定、颈动脉内-中膜厚度(IMT)测量,计算出AASI,进行AASI与尿白蛋白/尿肌酐比值(ACR)以及IMT等的相关性分析.结果 高血压组与正常对照组间相比,ACR(46.34与33.52)(P＜0.05)、微量白蛋白尿发生率(41％与21％)、IMT[(0.90 ±0.21)mm与(0.83±0.20)mm]、颈动脉异常发生率(72％与60％)以及AASI(0.50±0.16与0.42±0.17)间差异均有统计学意义(P均＜0.01),而ACR正常组与异常组比较,IMT正常组与异常组比较,异常组AASI均明显升高,差异具有统计学意义[分别为0.453±0.153与0.511±0.155,(0.453 ±0.156)mm与(0.535±0.157)mm,t值分别为2.210、2,809,P＜0.05、P＜0.01].结论 高血压患者的AASI与肾脏损害及颈动脉内膜损伤程度有明显相关性.
目的 研究高血壓患者的動態動脈硬化指數(AASI)與腎髒損害以及頸動脈內膜損傷的相關性.方法 篩選無糖尿病和其他緻動脈硬化疾病的高血壓患者149例,以及同期健康體檢者48名作為正常對照組,分彆行24h動態血壓鑑測(ABPM)及尿白蛋白及尿肌酐測定、頸動脈內-中膜厚度(IMT)測量,計算齣AASI,進行AASI與尿白蛋白/尿肌酐比值(ACR)以及IMT等的相關性分析.結果 高血壓組與正常對照組間相比,ACR(46.34與33.52)(P＜0.05)、微量白蛋白尿髮生率(41％與21％)、IMT[(0.90 ±0.21)mm與(0.83±0.20)mm]、頸動脈異常髮生率(72％與60％)以及AASI(0.50±0.16與0.42±0.17)間差異均有統計學意義(P均＜0.01),而ACR正常組與異常組比較,IMT正常組與異常組比較,異常組AASI均明顯升高,差異具有統計學意義[分彆為0.453±0.153與0.511±0.155,(0.453 ±0.156)mm與(0.535±0.157)mm,t值分彆為2.210、2,809,P＜0.05、P＜0.01].結論 高血壓患者的AASI與腎髒損害及頸動脈內膜損傷程度有明顯相關性.
목적 연구고혈압환자적동태동맥경화지수(AASI)여신장손해이급경동맥내막손상적상관성.방법 사선무당뇨병화기타치동맥경화질병적고혈압환자149례,이급동기건강체검자48명작위정상대조조,분별행24h동태혈압감측(ABPM)급뇨백단백급뇨기항측정、경동맥내-중막후도(IMT)측량,계산출AASI,진행AASI여뇨백단백/뇨기항비치(ACR)이급IMT등적상관성분석.결과 고혈압조여정상대조조간상비,ACR(46.34여33.52)(P＜0.05)、미량백단백뇨발생솔(41％여21％)、IMT[(0.90 ±0.21)mm여(0.83±0.20)mm]、경동맥이상발생솔(72％여60％)이급AASI(0.50±0.16여0.42±0.17)간차이균유통계학의의(P균＜0.01),이ACR정상조여이상조비교,IMT정상조여이상조비교,이상조AASI균명현승고,차이구유통계학의의[분별위0.453±0.153여0.511±0.155,(0.453 ±0.156)mm여(0.535±0.157)mm,t치분별위2.210、2,809,P＜0.05、P＜0.01].결론 고혈압환자적AASI여신장손해급경동맥내막손상정도유명현상관성.
Objective To investigate the relationship between Ambulatory Arterial Stiffness Index (AASI)and kidney damage or carotid endarterectomy damage in hypertension patients.Methods One hundred and forty-nine patients with hypertension but without diabetes or other arteriosclerosis diseases were enrolled.Forty-eight healthy volunteers during the same period were enrolled as control group.All participants'24 h-ambulatory blood pressure monitoring(ABPM),urinary albumin/creatinine ratio(ACR)and IMT were recorded and AASI was calculated.Then the correlation between AASI and ACR or IMT were calculated.Results There were significant differences in the urinary albumin/creatinine ratio(46.34 vs.33.52)(P ＜ 0.05),microalbuminuria incidence(41％ vs.21％),Carotid intima-media thickness([0.90 ±0.21]mm vs.[0.83 ±0.20]mm),abnormal incidence(72％ vs.60％)and AAS1(0.50 ± 0.16 vs.0.42 ± 0.17)(P ＜ 0.01)between the subjects with hypertension and those without.The AASI were positively correlated with ACR and IMT in hypertension patients.Compared with healthy subjects,the AASI were significantly increased in the patients with abnormal CR and IMT(P ＜0.05 、P ＜0.01).Conclusion The AASI were correlated with kidney damage and carotid endarterectomy damage in hypertension patients.
