中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2010年
3期
257-259
,共3页
组合型人工肾%血液透析%血液灌流%慢性肾衰竭%Meta分析
組閤型人工腎%血液透析%血液灌流%慢性腎衰竭%Meta分析
조합형인공신%혈액투석%혈액관류%만성신쇠갈%Meta분석
Hemoperfusion-hemodialysis%Hemodialysis%Hemoperfusion%Chronic renal failure%Meta-analysis
目的 评价组合型人工肾(HP+HD)治疗与血液透析(HD)治疗对慢性肾衰竭患者并发症的影响.方法 通过数据库检索国内相关文献,并按Cochrane协作网提供的Meta分析对其进行定量综合分析,比较两种不同透析方法治疗慢性肾衰竭患者后并发症的改善情况.结果 共11篇文献571例患者符合纳入标准.组合型人工肾组皮肤瘙痒未缓解率明显低于血液透析组,合并OR值为0.06,95%CI为(0.03,0.10);失眠未缓解率存在异质性(χ~2=10.02,P＜0.05),采用随机效应模型分析,合并OR值为0.29,95%CI为(0.10,0.83),P=0.02;食欲下降未缓解率与骨病和肌无力未缓解率均不存在异质性,采用固定效应模型分析,表明组合型人工肾治疗明显缓解了食欲下降、骨病和肌无力的症状.结论 组合型人工肾治疗在缓解慢性肾衰竭患者并发症方面优于血液透析治疗.
目的 評價組閤型人工腎(HP+HD)治療與血液透析(HD)治療對慢性腎衰竭患者併髮癥的影響.方法 通過數據庫檢索國內相關文獻,併按Cochrane協作網提供的Meta分析對其進行定量綜閤分析,比較兩種不同透析方法治療慢性腎衰竭患者後併髮癥的改善情況.結果 共11篇文獻571例患者符閤納入標準.組閤型人工腎組皮膚瘙癢未緩解率明顯低于血液透析組,閤併OR值為0.06,95%CI為(0.03,0.10);失眠未緩解率存在異質性(χ~2=10.02,P＜0.05),採用隨機效應模型分析,閤併OR值為0.29,95%CI為(0.10,0.83),P=0.02;食欲下降未緩解率與骨病和肌無力未緩解率均不存在異質性,採用固定效應模型分析,錶明組閤型人工腎治療明顯緩解瞭食欲下降、骨病和肌無力的癥狀.結論 組閤型人工腎治療在緩解慢性腎衰竭患者併髮癥方麵優于血液透析治療.
목적 평개조합형인공신(HP+HD)치료여혈액투석(HD)치료대만성신쇠갈환자병발증적영향.방법 통과수거고검색국내상관문헌,병안Cochrane협작망제공적Meta분석대기진행정량종합분석,비교량충불동투석방법치료만성신쇠갈환자후병발증적개선정황.결과 공11편문헌571례환자부합납입표준.조합형인공신조피부소양미완해솔명현저우혈액투석조,합병OR치위0.06,95%CI위(0.03,0.10);실면미완해솔존재이질성(χ~2=10.02,P＜0.05),채용수궤효응모형분석,합병OR치위0.29,95%CI위(0.10,0.83),P=0.02;식욕하강미완해솔여골병화기무력미완해솔균불존재이질성,채용고정효응모형분석,표명조합형인공신치료명현완해료식욕하강、골병화기무력적증상.결론 조합형인공신치료재완해만성신쇠갈환자병발증방면우우혈액투석치료.
Objective To evaluate the effects of combined hemoperfusion-hemodialysis(HP+HD) and hematodialysis (HD) on complications in patients with chronic renal failure (CRF).Methods A quantitative and comprehensive analysis was performed,based on the Meta analysis provided by Cochrane Cooperation Network,on the relative domestic leteratures retrieved from the database to compare the complications between CRF patients treated by 2 different dialyses.Results A total of 571 patients chosen from 11 literatures met the inclusion criteria.The non-remission rate of skin itch was significantly lower in HP+HD group than in HD group,with a pooled OR value of 0.06 (95% CI:0.03,0.10);that of insomnia was of heterogeneity(χ~2=10.02,P＜0.05),and its pooled OR value by random effect model analysis was 0.29 (95% CI:0.10,0.83,P=0.02);those of appetite loss,osteopathia and amyasthenia were of no heterogeneity and fixed-effect model analysis showed that HP+HD treatment had obviously alleviated the loss of appetite and the symptoms of osteopathia and amyasthenia.Conclusion HP+HD can alleviate effectively complications of CRF patients.
