合成化学
閤成化學
합성화학
CHINESE JOURNAL OF SYNTHETIC CHEMISTRY
2009年
6期
747-749
,共3页
张弦%王建新%武建利%孙培冬
張絃%王建新%武建利%孫培鼕
장현%왕건신%무건리%손배동
二异丙基酮%2,3-二甲基-2-异丙基-丁酸%羧化反应%合成
二異丙基酮%2,3-二甲基-2-異丙基-丁痠%羧化反應%閤成
이이병기동%2,3-이갑기-2-이병기-정산%최화반응%합성
diisopropyl ketone%2-isopropyl-2,3-dimethyl-butyric acid%carboxylation%synthesis
二异丙基酮与MeMgBr反应制备2,3,4-三甲基-3-戊醇;再经Koch-Haaf羧化反应合成了2,3-二甲基-2-异丙基-丁酸,总收率51%,其结构经NMR,IR和GC-MS确证.
二異丙基酮與MeMgBr反應製備2,3,4-三甲基-3-戊醇;再經Koch-Haaf羧化反應閤成瞭2,3-二甲基-2-異丙基-丁痠,總收率51%,其結構經NMR,IR和GC-MS確證.
이이병기동여MeMgBr반응제비2,3,4-삼갑기-3-무순;재경Koch-Haaf최화반응합성료2,3-이갑기-2-이병기-정산,총수솔51%,기결구경NMR,IR화GC-MS학증.
2-Isopropyl-2,3-dimethyl-butyric acid in total yield of 51% was synthesized by the reaction of diisopropyl ketone with Grignard reagent of bromomethane(MeMgBr) to obtain 2,3,4-trimethyl-3-pentanol, and then by Koch-Haaf carboxylation. The structure was confirmed by NMR, IR and GC-MS.
