中药新药与临床药理
中藥新藥與臨床藥理
중약신약여림상약리
TRADITIONAL CHINESE DRUG RESEARCH&CLINICAL PHARMACOLOGY
2010年
2期
119-122
,共4页
杨明华%柴可夫%杨苏蓓%金祖汉%金捷%毛培江%杨毅
楊明華%柴可伕%楊囌蓓%金祖漢%金捷%毛培江%楊毅
양명화%시가부%양소배%금조한%금첩%모배강%양의
糖瘀康颗粒%糖尿病模型%阴虚血瘀证%中医证候
糖瘀康顆粒%糖尿病模型%陰虛血瘀證%中醫證候
당어강과립%당뇨병모형%음허혈어증%중의증후
Tangyukang Granula%Diabetic Models%Yin Deficiency and Blood Stasis Syndrome%TCM syndrome pattern
目的 建立糖尿病阴虚血瘀证大鼠模型并观察糖瘀康颗粒的药效作用.方法 以高糖高脂饲料饲养SD大鼠,同时喂饲甲状腺素,再尾静脉注射低剂量四氧嘧啶(ALX)35 mg/kg,以复制糖尿病阴虚血瘀证大鼠模型.用降糖降脂、活血化瘀、生化免疫等指标观察糖瘀康的药效.结果 所建模型具有糖尿病症状和阴虚血瘀中医证候.糖瘀康能改善模型大鼠多饮、多食和阴虚血瘀状况,具有降糖降脂、活血化瘀及提高免疫力等作用.结论 糖尿病阴虚血瘀证大鼠模型造模成功.糖瘀康对模型大鼠具有防治作用.
目的 建立糖尿病陰虛血瘀證大鼠模型併觀察糖瘀康顆粒的藥效作用.方法 以高糖高脂飼料飼養SD大鼠,同時餵飼甲狀腺素,再尾靜脈註射低劑量四氧嘧啶(ALX)35 mg/kg,以複製糖尿病陰虛血瘀證大鼠模型.用降糖降脂、活血化瘀、生化免疫等指標觀察糖瘀康的藥效.結果 所建模型具有糖尿病癥狀和陰虛血瘀中醫證候.糖瘀康能改善模型大鼠多飲、多食和陰虛血瘀狀況,具有降糖降脂、活血化瘀及提高免疫力等作用.結論 糖尿病陰虛血瘀證大鼠模型造模成功.糖瘀康對模型大鼠具有防治作用.
목적 건립당뇨병음허혈어증대서모형병관찰당어강과립적약효작용.방법 이고당고지사료사양SD대서,동시위사갑상선소,재미정맥주사저제량사양밀정(ALX)35 mg/kg,이복제당뇨병음허혈어증대서모형.용강당강지、활혈화어、생화면역등지표관찰당어강적약효.결과 소건모형구유당뇨병증상화음허혈어중의증후.당어강능개선모형대서다음、다식화음허혈어상황,구유강당강지、활혈화어급제고면역력등작용.결론 당뇨병음허혈어증대서모형조모성공.당어강대모형대서구유방치작용.
Objective To establish rat models of diabetes with Yin deficiency and blood stasis syndrome (YDBS). and to investigate the preventive and therapeutic effect of Tangyukang Granula (TYK)on YDBS rats. Methods SD rats models with YDBS were reproduced by fed with high fat and high sugar diet, and thyroxine pills for 30 days, then by injected with 35 mg/kg alloxan into tail vein. Meanwhile, the therapeutic effect of TYK was investigated on YDBS rats. Results The established model had the characteristics of diabetes and YDBS. TYK could relieved the symptoms of polydipsia and polyphagia, and the manifestations of YDBS, showing an effect on decreasing blood glucose and lipid, activating blood and removing stasis, and improving immune function. Conclusion The diabetic rat model with YDBS is successfully established. TYK has preventive and therapeutic effect on YDBS rats.
