国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2009年
1期
31-33
,共3页
肺肿瘤%细胞凋亡%靶向治疗
肺腫瘤%細胞凋亡%靶嚮治療
폐종류%세포조망%파향치료
Lung neoplasms%Apoptosis%Target therapy
凋亡抑制蛋白Survivin具有抑制细胞凋亡和调节细胞周期作用,可选择性高表达在大多数恶性肿瘤中.最近研究表明Survivin过表达与肺癌发生发展、较差预后、放化疗抵抗相关联.Survivin可能成为恶性肿瘤早期诊断及基因治疗的靶点.
凋亡抑製蛋白Survivin具有抑製細胞凋亡和調節細胞週期作用,可選擇性高錶達在大多數噁性腫瘤中.最近研究錶明Survivin過錶達與肺癌髮生髮展、較差預後、放化療牴抗相關聯.Survivin可能成為噁性腫瘤早期診斷及基因治療的靶點.
조망억제단백Survivin구유억제세포조망화조절세포주기작용,가선택성고표체재대다수악성종류중.최근연구표명Survivin과표체여폐암발생발전、교차예후、방화료저항상관련.Survivin가능성위악성종류조기진단급기인치료적파점.
Survivin has an ability to inhibit cell apotosis and regulate cell cycle.It is selectively over-expressed in most human neoplasmas.Recent researches have shown that survivin over expression is associated with the earcinogensis, development, poor prognosis and drug/radiation resistant of lung cancer.Survivin may become a target of early diagnosis and gene therapy for malignant tumors.
