CAJ | 학술논문

目的探讨系统性硬皮病(SSc)患者血清自身抗体与临床之间的关系.方法对1981-2009年确诊为系统性硬皮病的283例患者的临床资料进行分析.结果 283例患者中,女253例(89.4%),平均发病年龄(35.9±12.6)岁,就诊时平均病程(4.3±4.5)年.弥漫性皮肤型SSc共125例(44.2%).ANA阳性96.8%,抗Scl-70抗体阳性54.4%,ACA阳性6.4%,抗RNP阳性23.7%,抗Sm抗体阳性7.1%,抗SSA抗体阳性25.1%,抗SSB抗体阳性7.1%,抗Jo-1抗体5H性1.1%,未检出抗rRNP抗体.抗Scl-70抗体、ACA均阳性者仪1例.在IcSSe中ACA阳性率较dcSSc中高(P<0.05).结论抗核抗体检测有助于对SSc患者进行诊断、分型、预后及处理.
목적 탐토계통성경피병(SSc)환자혈청자신항체여림상지간적관계.방법 대1981-2009년학진위계통성경피병적283례환자적림상자료진행분석.결과 283례환자중,녀253례(89.4%),평균발병년령(35.9±12.6)세,취진시평균병정(4.3±4.5)년.미만성피부형SSc공125례(44.2%).ANA양성96.8%,항Scl-70항체양성54.4%,ACA양성6.4%,항RNP양성23.7%,항Sm항체양성7.1%,항SSA항체양성25.1%,항SSB항체양성7.1%,항Jo-1항체5H성1.1%,미검출항rRNP항체.항Scl-70항체、ACA균양성자의1례.재IcSSe중ACA양성솔교dcSSc중고(P<0.05).결론 항핵항체검측유조우대SSc환자진행진단、분형、예후급처리.
objective To investigate the clinical relevance of antinuclear antibodies (ANA)in patients with systemic sclerosis(SSc).Methods Clinical data were collected from 283 patients with SSc admitted to Peking Union Medical College Hospital(PUMCH)from 1981 to 2009.A retrospective analysis was carried out.Results In the 283 patients,253(89.4%)were female.The mean age at onset was 35.9±12.6 years and mean disease duration 4.3 ±4.5 years.There were 125(44.2%)patients with diffuse SSc(dcSSc) and 158(55.8%)with limited cutaneous SSc(lcSSc).Of all the patients,96.8%were positive for ANA,54.4% for anti-Scl-70 antibodies,6.4%for anticentromere antibodies(ACA),23.7%for anti-ribonucleoprotein(RNP) antibodies,7.1%for anti-Sm antibodies,25.1%for anti-SSA antibodies,7.1%for anti.SSB antibodies,and 1.1%for anti-Jo-1 antibodies.No patients were positive for anti-rRNP antibodies.Only one patient was positive for both anti-Scl-70 antibodies and ACA.The positivity rate of ACA in patients with leSSe was higher thanthat in those with dcSSc(P<0.05).Conclusion The detection of antinuclear antibodies is helpful for the diagnosis,classification,prognosis evaluation and management of SSc.