上海交通大学学报（医学版）
上海交通大學學報（醫學版）
상해교통대학학보（의학판）
JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY(MEDICAL SCIENCE)
2009年
12期
1467-1470
,共4页
赵树田%张士青%顾欣%李建涛
趙樹田%張士青%顧訢%李建濤
조수전%장사청%고흔%리건도
结石预防型酸奶%市售酸奶%结石%草酸%大鼠
結石預防型痠奶%市售痠奶%結石%草痠%大鼠
결석예방형산내%시수산내%결석%초산%대서
kidney calcium oxalate calculus resistant acidophilus milk%commercially available acidophilus milk%calculus%oxalate%rat
目的 比较自制结石预防型酸奶(防石酸奶)与某市售品牌酸奶对大鼠尿草酸排泄量的影响.方法 50只SD大鼠随机分为5组(n=10),连续20 d分别每日灌喂4 mL自制防石酸奶(防石酸奶组)、某市售品牌酸奶(市售品牌酸奶组)、灭菌防石酸奶(灭菌防石酸奶组)、灭菌某市售品牌酸奶(灭菌市售品牌酸奶组)和去离子水(空白对照组),灌喂前1天及灌喂期间每隔4天测量大鼠体质量及24 h尿草酸排泄量.结果 灌喂期间,各组大鼠体质量和24 h尿草酸排泄量均逐渐增加;灭菌防石酸奶组、灭菌市售品牌酸奶组和空白对照组尿草酸排泄量差异无统计学意义(P>0.05);防石酸奶组和市售品牌酸奶组尿草酸排泄量的增加趋势明显小于其他三组,其分别于灌喂8 d和12 d后显著小于灭菌防石酸奶组和灭菌市售品牌酸奶组(P<0.05);防石酸奶组尿草酸排泄量于灌喂16 d后小于市售品牌酸奶组(P<0.05);各组大鼠体质量与24 h尿草酸排泄量呈正相关(r＝0.97～0.99,P<0.01).结论 自制防石酸奶与某市售品牌酸奶均可降低大鼠尿草酸排泄量,前者效果显著优于后者.
目的 比較自製結石預防型痠奶(防石痠奶)與某市售品牌痠奶對大鼠尿草痠排洩量的影響.方法 50隻SD大鼠隨機分為5組(n=10),連續20 d分彆每日灌餵4 mL自製防石痠奶(防石痠奶組)、某市售品牌痠奶(市售品牌痠奶組)、滅菌防石痠奶(滅菌防石痠奶組)、滅菌某市售品牌痠奶(滅菌市售品牌痠奶組)和去離子水(空白對照組),灌餵前1天及灌餵期間每隔4天測量大鼠體質量及24 h尿草痠排洩量.結果 灌餵期間,各組大鼠體質量和24 h尿草痠排洩量均逐漸增加;滅菌防石痠奶組、滅菌市售品牌痠奶組和空白對照組尿草痠排洩量差異無統計學意義(P>0.05);防石痠奶組和市售品牌痠奶組尿草痠排洩量的增加趨勢明顯小于其他三組,其分彆于灌餵8 d和12 d後顯著小于滅菌防石痠奶組和滅菌市售品牌痠奶組(P<0.05);防石痠奶組尿草痠排洩量于灌餵16 d後小于市售品牌痠奶組(P<0.05);各組大鼠體質量與24 h尿草痠排洩量呈正相關(r＝0.97～0.99,P<0.01).結論 自製防石痠奶與某市售品牌痠奶均可降低大鼠尿草痠排洩量,前者效果顯著優于後者.
목적 비교자제결석예방형산내(방석산내)여모시수품패산내대대서뇨초산배설량적영향.방법 50지SD대서수궤분위5조(n=10),련속20 d분별매일관위4 mL자제방석산내(방석산내조)、모시수품패산내(시수품패산내조)、멸균방석산내(멸균방석산내조)、멸균모시수품패산내(멸균시수품패산내조)화거리자수(공백대조조),관위전1천급관위기간매격4천측량대서체질량급24 h뇨초산배설량.결과 관위기간,각조대서체질량화24 h뇨초산배설량균축점증가;멸균방석산내조、멸균시수품패산내조화공백대조조뇨초산배설량차이무통계학의의(P>0.05);방석산내조화시수품패산내조뇨초산배설량적증가추세명현소우기타삼조,기분별우관위8 d화12 d후현저소우멸균방석산내조화멸균시수품패산내조(P<0.05);방석산내조뇨초산배설량우관위16 d후소우시수품패산내조(P<0.05);각조대서체질량여24 h뇨초산배설량정정상관(r＝0.97～0.99,P<0.01).결론 자제방석산내여모시수품패산내균가강저대서뇨초산배설량,전자효과현저우우후자.
Objective To compare the effects of kidney calcium oxalate calculus resistant acidophilus milk (KCOCRAM) versus commercially available acidophilus milk (CAAM) on urinary oxalate excretion in rats. Methods Fifty SD rats were randomly divided into 5 groups (n=10), and were bred with KCOCRAM (KCOCRAM group), CAAM (CAAM group), sterilized KCOCRAM (sterilized KCOCRAM group), sterilized CAAM (sterilized CAAM group) and water (blank control group), respectively for a consecutive 20 d, with 4 mL/d for each rat. The data of body weight and 24 h urinary oxalate excretion volume were obtained 1 d before breeding and every 4 d during breeding. Results During breeding, body weight and 24 h urinary oxalate excretion volume of each group increased with time. There was no significant difference in urinary oxalate excretion volume among sterilized KCOCRAM group, sterilized CAAM group and blank control group (P>0.05). The increase tendency of KCOCRAM group and CAAM group was weaker than that of the other three groups. The urinary oxalate excretion volume was significantly lower in KCOCRAM group than that in sterilized KCOCRAM group from 8 d after breeding, and that was significantly lower in CAAM group than that in sterilized CAAM group from 12 d after breeding (P<0.05). The urinary oxalate excretion volume was significantly lower in KCOCRAM group than that in CAAM group from 16 d after breeding (P<0.05). There was a positive correlationship between body weight and 24 h urinary oxalate excretion volume in each group (r＝0.97-0.99, P<0.01). Conclusion Both KCOCRAM and CAAM can reduce urinary oxalate excretion in rats, and the former has a more favourable effect.
