CAJ | 학술논문

目的探讨冠心痛患者血清载脂蛋白A5(ApoA5)的水平与冠状动脉病变严重程度的关系.方法测定冠心病患者(114例)和对照者(40例)的代、TG、HDL-C、LDL-C、载脂蛋白A5、载脂蛋白A1、载脂蛋白B、脂蛋白(a)[LP(a)]和尿酸(uA)的水平.按照冠状动脉病变程度将冠心病患者又分为1支病变组、2支病变组、3支病变组及弥漫病变组,分析比较这些组间ApoA5水平,并做相关性分析.结果与对照组比较,冠心病组ApoA5、HDL-C和载脂蛋白A1水平明显降低(P<0.01或P<0.05);TG、LP(a)和UA水平均明显升高(P<0.01或P<0.05);TC、LDL-C、载脂蛋白B水平差异均无统计学意义(P均>0.05).对照组、1支病变组、2支病变组、3支及弥漫病变组的ApoA5水平比较差异有统计学意义(F=18.605,P<0.01),随病变加重ApoA5水平逐渐降低,组间两两比较均有统计学意义(P<0.01或P<0.05).相关分析显示ApoA5水平与TG(r=-0.208,P=0.040)及LP(a)(r=-0.088,P<0.001)水平成显著负相关;与HDL-C(r=0.241,P=0.016)正相关.结论血清ApoA5水平与冠状动脉粥样硬化病变严重程度负相关.ApoA5水平降低是冠心病的危险因素.
목적 탐토관심통환자혈청재지단백A5(ApoA5)적수평여관상동맥병변엄중정도적관계.방법 측정관심병환자(114례)화대조자(40례)적대、TG、HDL-C、LDL-C、재지단백A5、재지단백A1、재지단백B、지단백(a)[LP(a)]화뇨산(uA)적수평.안조관상동맥병변정도장관심병환자우분위1지병변조、2지병변조、3지병변조급미만병변조,분석비교저사조간ApoA5수평,병주상관성분석.결과 여대조조비교,관심병조ApoA5、HDL-C화재지단백A1수평명현강저(P<0.01혹P<0.05);TG、LP(a)화UA수평균명현승고(P<0.01혹P<0.05);TC、LDL-C、재지단백B수평차이균무통계학의의(P균>0.05).대조조、1지병변조、2지병변조、3지급미만병변조적ApoA5수평비교차이유통계학의의(F=18.605,P<0.01),수병변가중ApoA5수평축점강저,조간량량비교균유통계학의의(P<0.01혹P<0.05).상관분석현시ApoA5수평여TG(r=-0.208,P=0.040)급LP(a)(r=-0.088,P<0.001)수평성현저부상관;여HDL-C(r=0.241,P=0.016)정상관.결론 혈청ApoA5수평여관상동맥죽양경화병변엄중정도부상관.ApoA5수평강저시관심병적위험인소.
Objective To study the relationship between severity of coronary artery lesion and serum level of apolipoprotein A5 (ApoA5). Methods The level of serum total cholesterol (TC), triglyceride (TG), high-den-sity lipoprotein cholesterol (HDL-C ), low density lipoprotein cholesterol (LDL-C ), apolipoprotein A1 ( APOA1), apolipoprotein B (APOB) ,Lipoprotein(a) and uric acid(UA) were examined in 114 patients with coronary heart disease(CHD) and 40 healthy control subjects;Enzyme-linked immunosorbent assay (ELISA) methods was used to determine APOA5. The eoronay heart disease patients were divided into tree groups by the severity of coronary artery lesion: that is one, two and three vessel lesion. Results Compared with control group, APOA5, ApoA1, HDL-C lev-el of CHD groups were lower(P <0.01 or P<0.05) ,TG ,LP(a)and UA were higher(P <0.01 or P <0.05) ,the difference of TC, LDL-C and APOB were not significant (P>0.05 ). In the subgroups of CHD patients, The serum APOA5 concentrations were signficant different between the CHD patients and control group( F=18.605 ,P<0.01 ). Along with the severity of coronary artery,the level of ApoA5 concentrations had a lower trend. The level of ApoA5 was negatively correlated with serum TG level ( r=-0.208, P=0.040) and LP (a) ( r=-0.088, P <0.001). The level of APOA5 had a positive correlation with the serum HDL-C (r= 0.241, P = 0.016). Conclusion There is negative correlation between severity of coronary artery lesion and serum level of ApoA5. The decrease of ApoA5 maybe a risk factor.