CAJ | 학술논문

目的研究影响初诊食管癌患者能量代谢的相关因素.方法对2008年11月至2009年6月新华医院40例初诊食管癌患者,采用营养风险筛查2002(NRS 2002)进行营养风险筛查,分别应用间接测热法和生物电阻抗法测定其静息能量消耗(REE)和人体组成成分.结果 67.5%的初诊食管癌患者存在营养风险,且营养风险评分与其前白蛋白及白蛋白水平分别呈负相关关系(r=-0.444,P=0.004;r=-0.386,P=0.014).REE实测值和Harris-Benedict公式REE预测值分别为(6770±1360)和(6021±841)kJ/d,两者具有相关性(r=0.503,P=0.001),且前者显著高于后者(P＜0.001).40例患者中,57.5%处于高代谢状态,30.0%处于正常代谢状态,12.5%处于低代谢状态.多元线性逐步回归分析显示,在众多营养指标中仅去脂组织对REE值的影响具有统计学意义(P＜0.001).结论去脂组织是初诊食管癌患者能量代谢的影响因素之一.
목적 연구영향초진식관암환자능량대사적상관인소.방법 대2008년11월지2009년6월신화의원40례초진식관암환자,채용영양풍험사사2002(NRS 2002)진행영양풍험사사,분별응용간접측열법화생물전조항법측정기정식능량소모(REE)화인체조성성분.결과 67.5%적초진식관암환자존재영양풍험,차영양풍험평분여기전백단백급백단백수평분별정부상관관계(r=-0.444,P=0.004;r=-0.386,P=0.014).REE실측치화Harris-Benedict공식REE예측치분별위(6770±1360)화(6021±841)kJ/d,량자구유상관성(r=0.503,P=0.001),차전자현저고우후자(P＜0.001).40례환자중,57.5%처우고대사상태,30.0%처우정상대사상태,12.5%처우저대사상태.다원선성축보회귀분석현시,재음다영양지표중부거지조직대REE치적영향구유통계학의의(P＜0.001).결론 거지조직시초진식관암환자능량대사적영향인소지일.
Objective To evaluate the possible factors that may influence the resting energy expenditure (REE) in patients with newly diagnosed esophageal cancer. Methods Totally, 40 patients with newly diagnosed esophageal cancer were prospectively collected from November 2008 to June 2009 in Xinhua Hospital. Nutritional risk screening 2002 (NRS 2002) was performed. REE and body composition were measured using indirect calorimetry and bioeletrical impedence method, respectively. Results Twenty-seven (67.5%) patients were found with nutrition risk, and NRS score was negatively correlated with prealbumin ( r = - 0.444, P = 0.004) and albumin levels (r = - 0.386, P = 0.014). Measured REE and predicted REE values were ( 6770 ± 1360) and (6021 ± 841 ) kJ/d, respectively (P ＜ 0.001 ). Among all 40 patients, 57.5% of them were hypermetabolic,30.0% were normal, and 12.5% were hypometabolic. Stepwise linear regression analysis showed that fat free mass was the only significant determinant variable for REE (P ＜ 0.001 ). Conclusion Fat free mass is a factor than can influence the energy metabolism in patients with newly diagnosed esophageal cancer.