中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2011年
8期
589-592
,共4页
毕业%陈晶晶%闫捷%曾涛%付强强%钟志霞%谢克勤
畢業%陳晶晶%閆捷%曾濤%付彊彊%鐘誌霞%謝剋勤
필업%진정정%염첩%증도%부강강%종지하%사극근
正己烷%大蒜油%神经保护作用%乙醇脱氢酶
正己烷%大蒜油%神經保護作用%乙醇脫氫酶
정기완%대산유%신경보호작용%을순탈경매
N-hexane%Garlic oil%Neuroprotective effects%ADH
目的 研究大蒜油(garlic oil,GO)对正己烷(n-hexane)所致大鼠周围神经损伤的保护作用及其机制.方法 雄性Wistar大鼠40只,随机分为正常对照组、模型组、大蒜油低剂量组和高剂量组(n=10);正常对照组动物给予等体积生理盐水灌胃,模型组和大蒜油低、高剂量组大鼠分别给予2000mg/kg正己烷灌胃,大蒜油低、高剂量组大鼠于正己烷灌胃前1 h分别给予40和80mg/kg大蒜油灌胃,每周6次,持续10周.每周测步态评分和转棒指数,监测大鼠周围神经损伤情况.10周末,断头处死大鼠,测定肝组织中乙醇脱氢酶(ADH)、丙二醛(MDA)、还原型谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)、总抗氧化能力(T-AOC)、抑制羟基自由基能力.结果 与正常对照组相比,模型组大鼠步态评分明显升高,差异有统计学意义(P<0.01),而转棒指数明显下降.肝脏中ADH活力[(3.64±0.73)U/mgpro]上升49.8%,肝脏中GSH-Px、T-AOC和抑制羟基自由基能力水平下降[分别为(182.0±41.7)、(1.10±0.27)、(162.1±26.1)U/mg pro],MDA含量[(1.89±0.42)nmol/mg pro]上升,与正常对照组[分别为(2.43±0.54)U/mgpro、(273.3±48.8)U/mg pro、(1.89±0.42)U/mg pro、(196.3±36.9)U/mg pro、(1.28±0.28)nmol/mg pro]的差异均有统计学意义(P<0.05或P<0.01).与模型组相比,大蒜油低、高剂量组大鼠步态评分明显降低,差异有统计学意义(P<0.05),而转棒指数明显升高,差异均有统计学意义(P<0.05或P<0.01);与正常对照组相比,肝脏中ADH活力分别降低了25.3%和86.0%,GSH-Px、GSH、T-AOC及抑制羟基自由基能力水平明显上升,MDA含量明显下降,差异均有统计学意义(P<0.05或P<0.01).结论 大蒜油能够有效拮抗正己烷诱导所致的外周神经损伤,其机制可能与肝脏ADH活力降低有关.
目的 研究大蒜油(garlic oil,GO)對正己烷(n-hexane)所緻大鼠週圍神經損傷的保護作用及其機製.方法 雄性Wistar大鼠40隻,隨機分為正常對照組、模型組、大蒜油低劑量組和高劑量組(n=10);正常對照組動物給予等體積生理鹽水灌胃,模型組和大蒜油低、高劑量組大鼠分彆給予2000mg/kg正己烷灌胃,大蒜油低、高劑量組大鼠于正己烷灌胃前1 h分彆給予40和80mg/kg大蒜油灌胃,每週6次,持續10週.每週測步態評分和轉棒指數,鑑測大鼠週圍神經損傷情況.10週末,斷頭處死大鼠,測定肝組織中乙醇脫氫酶(ADH)、丙二醛(MDA)、還原型穀胱甘肽(GSH)、穀胱甘肽過氧化物酶(GSH-Px)、總抗氧化能力(T-AOC)、抑製羥基自由基能力.結果 與正常對照組相比,模型組大鼠步態評分明顯升高,差異有統計學意義(P<0.01),而轉棒指數明顯下降.肝髒中ADH活力[(3.64±0.73)U/mgpro]上升49.8%,肝髒中GSH-Px、T-AOC和抑製羥基自由基能力水平下降[分彆為(182.0±41.7)、(1.10±0.27)、(162.1±26.1)U/mg pro],MDA含量[(1.89±0.42)nmol/mg pro]上升,與正常對照組[分彆為(2.43±0.54)U/mgpro、(273.3±48.8)U/mg pro、(1.89±0.42)U/mg pro、(196.3±36.9)U/mg pro、(1.28±0.28)nmol/mg pro]的差異均有統計學意義(P<0.05或P<0.01).與模型組相比,大蒜油低、高劑量組大鼠步態評分明顯降低,差異有統計學意義(P<0.05),而轉棒指數明顯升高,差異均有統計學意義(P<0.05或P<0.01);與正常對照組相比,肝髒中ADH活力分彆降低瞭25.3%和86.0%,GSH-Px、GSH、T-AOC及抑製羥基自由基能力水平明顯上升,MDA含量明顯下降,差異均有統計學意義(P<0.05或P<0.01).結論 大蒜油能夠有效拮抗正己烷誘導所緻的外週神經損傷,其機製可能與肝髒ADH活力降低有關.
목적 연구대산유(garlic oil,GO)대정기완(n-hexane)소치대서주위신경손상적보호작용급기궤제.방법 웅성Wistar대서40지,수궤분위정상대조조、모형조、대산유저제량조화고제량조(n=10);정상대조조동물급여등체적생리염수관위,모형조화대산유저、고제량조대서분별급여2000mg/kg정기완관위,대산유저、고제량조대서우정기완관위전1 h분별급여40화80mg/kg대산유관위,매주6차,지속10주.매주측보태평분화전봉지수,감측대서주위신경손상정황.10주말,단두처사대서,측정간조직중을순탈경매(ADH)、병이철(MDA)、환원형곡광감태(GSH)、곡광감태과양화물매(GSH-Px)、총항양화능력(T-AOC)、억제간기자유기능력.결과 여정상대조조상비,모형조대서보태평분명현승고,차이유통계학의의(P<0.01),이전봉지수명현하강.간장중ADH활력[(3.64±0.73)U/mgpro]상승49.8%,간장중GSH-Px、T-AOC화억제간기자유기능력수평하강[분별위(182.0±41.7)、(1.10±0.27)、(162.1±26.1)U/mg pro],MDA함량[(1.89±0.42)nmol/mg pro]상승,여정상대조조[분별위(2.43±0.54)U/mgpro、(273.3±48.8)U/mg pro、(1.89±0.42)U/mg pro、(196.3±36.9)U/mg pro、(1.28±0.28)nmol/mg pro]적차이균유통계학의의(P<0.05혹P<0.01).여모형조상비,대산유저、고제량조대서보태평분명현강저,차이유통계학의의(P<0.05),이전봉지수명현승고,차이균유통계학의의(P<0.05혹P<0.01);여정상대조조상비,간장중ADH활력분별강저료25.3%화86.0%,GSH-Px、GSH、T-AOC급억제간기자유기능력수평명현상승,MDA함량명현하강,차이균유통계학의의(P<0.05혹P<0.01).결론 대산유능구유효길항정기완유도소치적외주신경손상,기궤제가능여간장ADH활력강저유관.
Objective To study the protective effects of garlic oil (GO) on the peripheral nerve injuries induced by n-hexane.Methods Male Wistar rats were randomly divided into four groups ( 10 rats in each group):the control, the n-hexane treatment ( 2000 mg/kg), the low dose GO, and the high dose GO groups.The rats in the low and high doses of GO groups were pretreated with GO (40 and 80 mg/kg) before exposure to n-hexane (2000 mg/kg ), while the animals of the n-hexane treatment group were given normal saline and then 2000 mg/kg n-hexane.The rats were exposed to GO and n-hexane 6 times a week for 10 weeks.The gait scores and staying time on the rotating rod for all rats were detected every two weeks.The rats were sacrificed at the end of ten weeks,then the levels of alcohol dehydrogenase (ADH), maleic dialdehyde (MDA), reduced glutathione OH in livers were examined.Results The gait scores increased significantly and the time staying on the rotating rod obviously decreased in rats of n-hexane treatment group, as compared with control group (P<0.05 or P<0.01 ).In the hepatic tissues of n-hexane group, the levels of MDA and ADH significantly increased, the group (P<0.05 or P<0.01 ).In 2 GO groups, the gait scores and the staying time on the rotating rod were significantly improved, the levels of MDA and ADH significantly decreased, the activities of GSH-Px, T-AOCConclusion ADH could play an important role in the protective effects induced by garlic oil on the peripheral nerve injuries produced by n-hexane.