中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2010年
42期
2967-2970
,共4页
吕丽芳%王椿%杨阎峙%何利平%刘关键%陈大伟%钟莉%陈利鸿%田浩明%周健%贾伟平%冉兴无
呂麗芳%王椿%楊閻峙%何利平%劉關鍵%陳大偉%鐘莉%陳利鴻%田浩明%週健%賈偉平%冉興無
려려방%왕춘%양염치%하리평%류관건%진대위%종리%진리홍%전호명%주건%가위평%염흥무
糖尿病%血糖自我监测%准确度%安全性
糖尿病%血糖自我鑑測%準確度%安全性
당뇨병%혈당자아감측%준학도%안전성
Diabetes%Blood glucose Self-monitoring%Accuracy%Safety
目的 评价动态血糖监测系统(CGMS)在正常人、糖调节异常和初诊2型糖尿病患者血糖监测中的准确性和安全性.方法 本研究纳入2007年11月至2009年10月期间在四川大学华西医院门诊/住院受试者162例,其中糖调节异常53例,初诊2型糖尿病患者56例,糖耐量正常53名.所有受试者佩戴CCMS 3 d,同时每天输入7次指尖血糖(SMBG)值进行校正,以评价CGMS的准确性及其与SMBG值的相关性,用Clarke误差表格进行两者一致性分析.结果 所有受试者均完成人均(75.6±8.3)h的动态血糖监测(CGM),获得4324对CGM值和SMBG值,两者间差异无统计学意义(P>0.05),且具有良好的相关性(r=0.943,P=0.000).87.16%的CGM值在SMBG值的±0.8 mmol/L或±20%范围内,CGM值与SMBG绝对差值的中位数为0.5(0.2～0.9)mmol/L,绝对差值的相对数的中位数为7.55%(3.33%～14.09%);Clarke误差表格分析显示CGM值87.5%在A区(临床准确区),12.1%在B区(临床可接受区).结论 CGMS具有良好的准确性、安全性和耐受性.
目的 評價動態血糖鑑測繫統(CGMS)在正常人、糖調節異常和初診2型糖尿病患者血糖鑑測中的準確性和安全性.方法 本研究納入2007年11月至2009年10月期間在四川大學華西醫院門診/住院受試者162例,其中糖調節異常53例,初診2型糖尿病患者56例,糖耐量正常53名.所有受試者珮戴CCMS 3 d,同時每天輸入7次指尖血糖(SMBG)值進行校正,以評價CGMS的準確性及其與SMBG值的相關性,用Clarke誤差錶格進行兩者一緻性分析.結果 所有受試者均完成人均(75.6±8.3)h的動態血糖鑑測(CGM),穫得4324對CGM值和SMBG值,兩者間差異無統計學意義(P>0.05),且具有良好的相關性(r=0.943,P=0.000).87.16%的CGM值在SMBG值的±0.8 mmol/L或±20%範圍內,CGM值與SMBG絕對差值的中位數為0.5(0.2～0.9)mmol/L,絕對差值的相對數的中位數為7.55%(3.33%～14.09%);Clarke誤差錶格分析顯示CGM值87.5%在A區(臨床準確區),12.1%在B區(臨床可接受區).結論 CGMS具有良好的準確性、安全性和耐受性.
목적 평개동태혈당감측계통(CGMS)재정상인、당조절이상화초진2형당뇨병환자혈당감측중적준학성화안전성.방법 본연구납입2007년11월지2009년10월기간재사천대학화서의원문진/주원수시자162례,기중당조절이상53례,초진2형당뇨병환자56례,당내량정상53명.소유수시자패대CCMS 3 d,동시매천수입7차지첨혈당(SMBG)치진행교정,이평개CGMS적준학성급기여SMBG치적상관성,용Clarke오차표격진행량자일치성분석.결과 소유수시자균완성인균(75.6±8.3)h적동태혈당감측(CGM),획득4324대CGM치화SMBG치,량자간차이무통계학의의(P>0.05),차구유량호적상관성(r=0.943,P=0.000).87.16%적CGM치재SMBG치적±0.8 mmol/L혹±20%범위내,CGM치여SMBG절대차치적중위수위0.5(0.2～0.9)mmol/L,절대차치적상대수적중위수위7.55%(3.33%～14.09%);Clarke오차표격분석현시CGM치87.5%재A구(림상준학구),12.1%재B구(림상가접수구).결론 CGMS구유량호적준학성、안전성화내수성.
Objective To evaluate the accuracy and safety of continuous glucose monitoring system (CGMS) in subjects with normal glucose tolerance (NGT), impaired glucose regulation (IGR) and newlydiagnosed type 2 diabetes mellitus (T2DM). Methods A total of 162 subjects(53 NGT, 53 IGR and 56newly diagnosed T2DM) at 22 -72 years old were recruited. Each subject received a continuous glucose monitoring(CGM) of CGMS(R) SYSTEM GOLDTM (Medtronic Minimed, Northridge,CA) for 3 consecutive days and was instructed to self-calibrate the interstitial glucose levels with finger-stick blood glucose measurements (self-monitoring of blood glucose, SMBG)7 times daily. Means of median absolute difference (median AD) and median absolute relative difference (median RAD) were calculated to assess the difference between CGM and SMBG values. The correlation between CGM and SMBG values were analyzed with the liner regression analysis. The data were analyzed by the ISO criteria for home glucose meters and Clarke error grid analysis. Results All participants showed a good tolerance to the insertion of CGMS sensor and wearing the device. The mean duration of CGMS recording was (75.6±8.3) h. A total of 4324 glucose meter values were paired with glucose measurements from CGMS. Overall, a good relationship (r=0.943,P = 0.000) and no significant difference (P >0.05) over a wide range(2.2-22.2mmol/L) were found between CGM and SMBG values. The median AD was 0.5 (0.2-0.9) mmol/L and the median RAD 7.55% (3.33%-14.09%) with 87.16% of sensor values meeting the ISO home glucose meter criteria.The Clarke error grid analysts showed that 99. 58% of the readings from CGMS fell into the clinical acceptable zones including 87.5% values in zone A (clinical exact) and 12.1% values in zone B (benign error). Conclusion Both safe and well-tolerated, continuous glucose monitoring provides comparatively accurate blood glucose values to guide the diagnosis and treatment of diabetes.
