CAJ | 학술논문

目的比较正常组、阿尔茨海默病(AD)组与帕金森病(PD)组的智力、记忆功能,比较正常组、AD病组与PD组脑脊液中Aβ42水平,分析三组间智力、记忆功能与脑脊液中Aβ42水平的相关性.方法采用韦氏成人智力量表及韦氏记忆量表分别对30例正常组、30例AD组及30例PD组患者进行检测,采用酶联免疫吸附测定(ELISA)方法对三组患者脑脊液中Aβ42水平进行检测,对三组实验数据进行相关性分析.结果 AD组与PD组的智力、记忆功能明显低于对照组(P ＜0.05,P＜0.01),且AD组的智力、记忆功能明显低于PD组(P＜0.01)；AD病组与PD组脑脊液中Aβ42水平明显低于正常对照组(P＜0.05),且AD脑脊液中Aβ42水平组明显低于PD组(P＜0.01)；三组中Aβ42水平的降低程度与智力、记忆功能受损程度成正相关.结论智力和记忆的检测以及脑脊液中Aβ42水平的检测为AD和PD的鉴别诊断提供了依据.
목적 비교정상조、아이자해묵병(AD)조여파금삼병(PD)조적지력、기억공능,비교정상조、AD병조여PD조뇌척액중Aβ42수평,분석삼조간지력、기억공능여뇌척액중Aβ42수평적상관성.방법 채용위씨성인지역량표급위씨기억량표분별대30례정상조、30례AD조급30례PD조환자진행검측,채용매련면역흡부측정(ELISA)방법대삼조환자뇌척액중Aβ42수평진행검측,대삼조실험수거진행상관성분석.결과 AD조여PD조적지력、기억공능명현저우대조조(P ＜0.05,P＜0.01),차AD조적지력、기억공능명현저우PD조(P＜0.01)；AD병조여PD조뇌척액중Aβ42수평명현저우정상대조조(P＜0.05),차AD뇌척액중Aβ42수평조명현저우PD조(P＜0.01)；삼조중Aβ42수평적강저정도여지력、기억공능수손정도성정상관.결론 지력화기억적검측이급뇌척액중Aβ42수평적검측위AD화PD적감별진단제공료의거.
Objective To compare the intelligence and memory function of Alzheimer' s disease (AD),Parkinson' s disease (PD) and normal aged.To compare the CSF levels of amyloid - β protein(Aβ42) of them.To investigate the relationship between the intelligence,memory function and the CSF levels of Aβ42.Methods Thirty normal ageds,AD and PD were analyzed by the Wechsler adult intelligence scale and memory scale revised in China,the levels of Aβ42 in CSF were analyzed by Elisa.The relation between them was analyzed.Results The intelligence and memory function of AD and PD groups were depressed obviously compared with normal group (P ＜ 0.05 ),and AD group was depressed obviously compared with PD group (P ＜ 0.01 ).The Aβ42 levels in CSF of AD and PD groups were depressed obviously compared with normal group ( P ＜ 0.05 ),and AD group was depressed obviously compare with PD group (P ＜ 0.01 ).There were positive correlations between them.Conclusions Intelligence,memory function and Aβ42 levels in CSF are the differential diagnosis basis for AD and PD.