中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2008年
10期
764-767
,共4页
段钰%于丽娟%陆佩欧%王文志
段鈺%于麗娟%陸珮歐%王文誌
단옥%우려연%륙패구%왕문지
肺肿瘤%PET-CT%18F-氟代脱氧葡萄糖%标准摄取值%肿瘤分子生物学指标
肺腫瘤%PET-CT%18F-氟代脫氧葡萄糖%標準攝取值%腫瘤分子生物學指標
폐종류%PET-CT%18F-불대탈양포도당%표준섭취치%종류분자생물학지표
Lungncoplasms%PET/CT%18F-FDG%SUV%Tumoral molecular-biological index
目的 分析非小细胞肺癌(NSCLC)18F-氟代脱氧葡萄糖(18F-FDG)标准摄取值(SUV)与葡萄糖转运蛋白l(GLUTl)、微血管密度(MVD)及Ki67表达的相关性.方法 收集经18F-FDGPET-CT检查并手术切除的NSCLC 33例,采用免疫组织化学DP法,分别检测GLUTl、MVD和Ki67,并将三者与18F-FIX;的SUV进行对比.结果 33例NSCLC患者中,Ⅰ期21例,Ⅱ期4例,Ⅲa期8例.33例NSCLC标本中,GLUTl阳性者22例(12例腺癌,10例鳞癌),阴性者11例(10例腺癌,1例鳞癌),阳性率为66.7%;Ki67阳性者24例(13例腺癌,11例鳞癌),阴性者9例(均为腺癌),阳性率为72.7%;CD34阳性者33例,阳性率为100.0%,标本平均MVD为(12.6±2.9)条,33例NSCLC的SUV为1.4～27.4,中位数为10.1.结论 18F-FDlG PET的SUV与GLUTl呈线性相关,SUV与Ki67表达和MVD无相关性.GLUTl、Ki67和CD34与病灶大小及有无淋巴结转移无相关性.
目的 分析非小細胞肺癌(NSCLC)18F-氟代脫氧葡萄糖(18F-FDG)標準攝取值(SUV)與葡萄糖轉運蛋白l(GLUTl)、微血管密度(MVD)及Ki67錶達的相關性.方法 收集經18F-FDGPET-CT檢查併手術切除的NSCLC 33例,採用免疫組織化學DP法,分彆檢測GLUTl、MVD和Ki67,併將三者與18F-FIX;的SUV進行對比.結果 33例NSCLC患者中,Ⅰ期21例,Ⅱ期4例,Ⅲa期8例.33例NSCLC標本中,GLUTl暘性者22例(12例腺癌,10例鱗癌),陰性者11例(10例腺癌,1例鱗癌),暘性率為66.7%;Ki67暘性者24例(13例腺癌,11例鱗癌),陰性者9例(均為腺癌),暘性率為72.7%;CD34暘性者33例,暘性率為100.0%,標本平均MVD為(12.6±2.9)條,33例NSCLC的SUV為1.4～27.4,中位數為10.1.結論 18F-FDlG PET的SUV與GLUTl呈線性相關,SUV與Ki67錶達和MVD無相關性.GLUTl、Ki67和CD34與病竈大小及有無淋巴結轉移無相關性.
목적 분석비소세포폐암(NSCLC)18F-불대탈양포도당(18F-FDG)표준섭취치(SUV)여포도당전운단백l(GLUTl)、미혈관밀도(MVD)급Ki67표체적상관성.방법 수집경18F-FDGPET-CT검사병수술절제적NSCLC 33례,채용면역조직화학DP법,분별검측GLUTl、MVD화Ki67,병장삼자여18F-FIX;적SUV진행대비.결과 33례NSCLC환자중,Ⅰ기21례,Ⅱ기4례,Ⅲa기8례.33례NSCLC표본중,GLUTl양성자22례(12례선암,10례린암),음성자11례(10례선암,1례린암),양성솔위66.7%;Ki67양성자24례(13례선암,11례린암),음성자9례(균위선암),양성솔위72.7%;CD34양성자33례,양성솔위100.0%,표본평균MVD위(12.6±2.9)조,33례NSCLC적SUV위1.4～27.4,중위수위10.1.결론 18F-FDlG PET적SUV여GLUTl정선성상관,SUV여Ki67표체화MVD무상관성.GLUTl、Ki67화CD34여병조대소급유무림파결전이무상관성.
Objective To investigate the correlation between 18F-FDG standard uptake value (SUV) and expression of GLUT1, MVD and Ki67 in non-small cell lung cancer (NSCLC).Methods Thirty-three patients with non-small cell lung cancer received preoperative 18F-FDG PET-CT examination and underwent surgery.The expression of GLUTl, MVD and Ki67 were detected by immunohistnohemstry.The correlation between the SUV of 18F-FDG PET-CT and the immunohistochemical results of the three above mentioned parameters was analyzed.Results Of the 33 NSCLC patients, 21 were in stage Ⅰ , 4 in stage Ⅱ and 8 in stage Ⅲ a.Positive expression of GLUTl was found in 22 cases (66.7%, 12 adenocareinomas and 10 squamous cell carcinomas), and negative expression in 11 cases (10 adenocarcinomas and 1 squamous cell carcinoma).Twenty-four patients (72.7%) showed positive expression of Ki67 (13 adenocareinomas and 11 squamous cell carcinomas), and other 9 (adenocarcinomas) had negative expression.The positive expression rate of CD34 in this series was 100.0% with a mean MVD of 12.6±2.9.Conclusion SUV of 18F-FDG PET-CT is linearly correlated with the expression of GLUTl, but not with the expression of K167 or MVD.The expression of GLUTI, Ki67 and CD34 is not correlated with tumor size and lymph node metastasis.
