中药新药与临床药理
中藥新藥與臨床藥理
중약신약여림상약리
TRADITIONAL CHINESE DRUG RESEARCH&CLINICAL PHARMACOLOGY
2001年
1期
11-14
,共4页
李彩熙%金龙%李军梅%董晓霞%刘建勋%张绍来%刘士义
李綵熙%金龍%李軍梅%董曉霞%劉建勛%張紹來%劉士義
리채희%금룡%리군매%동효하%류건훈%장소래%류사의
@肾炎颗粒/药理学%肾小球肾炎,膜性/预防和控制%肾功 能衰竭,慢性/预防和控制%小鼠/免疫学%疾病模型,动物
@腎炎顆粒/藥理學%腎小毬腎炎,膜性/預防和控製%腎功 能衰竭,慢性/預防和控製%小鼠/免疫學%疾病模型,動物
@신염과립/약이학%신소구신염,막성/예방화공제%신공 능쇠갈,만성/예방화공제%소서/면역학%질병모형,동물
@Shenyan Keli/pharmacology%glomerul onephritis,membranous/prevention and control%kidney failure,chronic /prevent ion and control%disease models,animal
利用实验性膜性肾炎、慢性肾衰及水负荷大鼠的动物模型，探 讨肾炎颗粒对实验性膜 性肾炎和肾衰的治疗作用及利尿作用，并观察了该药对正常小鼠免疫功能的影响。结果显示 ，该药能减轻由阳离子化白蛋白和腺嘌呤引起的肾组织损伤，改善肾功能障碍和脂蛋白代谢 紊乱；增强水负荷大鼠的利尿作用；能提高正常小鼠的免疫功能。
利用實驗性膜性腎炎、慢性腎衰及水負荷大鼠的動物模型，探 討腎炎顆粒對實驗性膜 性腎炎和腎衰的治療作用及利尿作用，併觀察瞭該藥對正常小鼠免疫功能的影響。結果顯示 ，該藥能減輕由暘離子化白蛋白和腺嘌呤引起的腎組織損傷，改善腎功能障礙和脂蛋白代謝 紊亂；增彊水負荷大鼠的利尿作用；能提高正常小鼠的免疫功能。
이용실험성막성신염、만성신쇠급수부하대서적동물모형，탐 토신염과립대실험성막 성신염화신쇠적치료작용급이뇨작용，병관찰료해약대정상소서면역공능적영향。결과현시 ，해약능감경유양리자화백단백화선표령인기적신조직손상，개선신공능장애화지단백대사 문란；증강수부하대서적이뇨작용；능제고정상소서적면역공능。
The therapeutic and diuretic effects of Sheny an Keli on experimental ra ts with membranous nephritis ,chronic renal failure and overhydration were obser ved. And its effect on immune function in normal mice was also studied .The results showed Shenyan Keli can reduce the damage of kidney tissue indu ced by cationize d albumin and amidopurine, correct the disturbances of renal function and lipop rotein metabolism and increase the diuretic effect on water-loaded rats. In addi t ion, Shenyan Keli can also enhance the immune function in norma l mice.
