CAJ | 학술논문

环境内分泌干扰物(environmental endocrine disruptor,EED)是具有干扰机体内分泌系统的一类外源性化学物质.研究表明性激素合成相关酶基因是EED的重要靶点.性激素合成与代谢的失衡可致机体生殖障碍、性分化、性发育异常及某些癌症的发病风险增加等.其中类固醇合成急性调节蛋白、芳香化酶等是性激素合成的限速酶及关键酶,这些酶及蛋白又受一系列转录因子及信号通路的调控.基于在性激素合成中的特殊作用,这些酶、转录因子及信号通路等组成的基因调控网络与EED之间的关系备受关注.遗传背景的差异性可影响机体对EED的敏感性.该文就近年来性激素合成相关酶基因的调控以及EED对其产生的不良影响作一综述.
배경내분비간우물(environmental endocrine disruptor,EED)시구유간우궤체내분비계통적일류외원성화학물질.연구표명성격소합성상관매기인시EED적중요파점.성격소합성여대사적실형가치궤체생식장애、성분화、성발육이상급모사암증적발병풍험증가등.기중류고순합성급성조절단백、방향화매등시성격소합성적한속매급관건매,저사매급단백우수일계렬전록인자급신호통로적조공.기우재성격소합성중적특수작용,저사매、전록인자급신호통로등조성적기인조공망락여EED지간적관계비수관주.유전배경적차이성가영향궤체대EED적민감성.해문취근년래성격소합성상관매기인적조공이급EED대기산생적불량영향작일종술.
Environmental endocrine disruptors (EED) are pollutants of many exogenous chemicals,which have the potential to disrupt endocrine functions in exposed organisms.The enzymes increasingly involved in the steroid biosynthesis pathway are being recognized as important targets for the actions of various endocrine disrupting chemicals.Interferences with steroid biosynthesis may result in impaired reproduction,alterations in sexual differentiation,sexual development and the development of certain cancers.Aromatase ( CYP19 ) and steroidogenic acute regulatory protein regulated by some transcriptional factors and signalling pathway are considered as the key and rate-limiting enzymes.Given their key role in the formation of steroid hormones,gene regulatory networks of enzymes related to steroidogenesis are gaining interest as molecular targets.Differences in genetic background can affect body's sensitivity to EED.This review will provide an overview of the enzymes involved in steroidogenesis,their cellular and molecular regulation,as well as the adverse effect of EED on them.