CAJ | 학술논문

乳腺癌易感基因的研究对有乳腺癌家族史的个体进行早诊和预防、阐明散发性乳腺癌发病机制、早诊、判断药物敏感性和预后、鉴别诊断良恶性疾病等均有重要意义.BRCA1和BRCA2是乳腺癌主要易感基因.其他易感基因诸如TP53能增加BRCA1、BRCA2的乳腺癌患病风险.
유선암역감기인적연구대유유선암가족사적개체진행조진화예방、천명산발성유선암발병궤제、조진、판단약물민감성화예후、감별진단량악성질병등균유중요의의.BRCA1화BRCA2시유선암주요역감기인.기타역감기인제여TP53능증가BRCA1、BRCA2적유선암환병풍험.
The study on susceptibility genes play an important role in early diagnosis and prevention for the individuals with family history of breast carcinoma,elucidation of pathologic mechanism of sporadic breast carcinoma,early diagnosis and adjudging prognosis,research on drug sensitivity,differential diagnosis of benign and malignant disease,etc.Two major susceptibility genes for breast cancer,BRCA1 and BRCA2,are identified,respectively.Other tumor susceptibility genes such as TP53 are known to increase breast cancer risk of BRCA1 and BRCA2.