中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2010年
5期
321-324
,共4页
闫永建%李秀菊%宁国英%赵学斌%潘永峰%闫晓勇%李治红%张修伟%孙明霞%李利
閆永建%李秀菊%寧國英%趙學斌%潘永峰%閆曉勇%李治紅%張脩偉%孫明霞%李利
염영건%리수국%저국영%조학빈%반영봉%염효용%리치홍%장수위%손명하%리리
有机磷化合物%农药%临床方案
有機燐化閤物%農藥%臨床方案
유궤린화합물%농약%림상방안
Organophosphorus compounds%Pesticides%Cclimical plan
目的 探讨急性有机磷中毒(AOPP)规范化治疗方案.方法 在前期研究的基础上,建立AOPP规范化治疗方案,选择某省农药中毒高发区6家医院开展临床试验研究.结果 6家医院观察期内按照统一规范治疗方案共观察治疗AOPP患者422例,以口服中毒为主(97.16%),中、重度患者占87.44%.以规范治疗前2年的病例作为对照,采用规范治疗后,定点医院AOPP病死率从9.87%降至1.66%,差异有统计学意义(χ2=27.92,P<0.01),明显低于同期该省报告综合救治水平(病死率为8.92%),差异亦有统计学意义(χ2=26.05,P<0.01).规范治疗组阿托品平均用量为(37.54±17.76)mg,较传统治疗组[(1280.70±69.22)mg]明显下降,差异有统计学意义(U=439.22,P<0.01),静脉泵给药优于静脉注射给药.规范治疗组氯解磷定平均用量为(25.55±13.78)g,较传统治疗组[(12.11±3.56)g]明显增加,差异有统计学意义(U=19.48,P<0.01).未见药物中毒现象.结论 AOPP治疗亟须规范,特别在广大农村地区.此次建立的规范治疗方案取得满意疗效,可明显降低AOPP病死率.
目的 探討急性有機燐中毒(AOPP)規範化治療方案.方法 在前期研究的基礎上,建立AOPP規範化治療方案,選擇某省農藥中毒高髮區6傢醫院開展臨床試驗研究.結果 6傢醫院觀察期內按照統一規範治療方案共觀察治療AOPP患者422例,以口服中毒為主(97.16%),中、重度患者佔87.44%.以規範治療前2年的病例作為對照,採用規範治療後,定點醫院AOPP病死率從9.87%降至1.66%,差異有統計學意義(χ2=27.92,P<0.01),明顯低于同期該省報告綜閤救治水平(病死率為8.92%),差異亦有統計學意義(χ2=26.05,P<0.01).規範治療組阿託品平均用量為(37.54±17.76)mg,較傳統治療組[(1280.70±69.22)mg]明顯下降,差異有統計學意義(U=439.22,P<0.01),靜脈泵給藥優于靜脈註射給藥.規範治療組氯解燐定平均用量為(25.55±13.78)g,較傳統治療組[(12.11±3.56)g]明顯增加,差異有統計學意義(U=19.48,P<0.01).未見藥物中毒現象.結論 AOPP治療亟鬚規範,特彆在廣大農村地區.此次建立的規範治療方案取得滿意療效,可明顯降低AOPP病死率.
목적 탐토급성유궤린중독(AOPP)규범화치료방안.방법 재전기연구적기출상,건립AOPP규범화치료방안,선택모성농약중독고발구6가의원개전림상시험연구.결과 6가의원관찰기내안조통일규범치료방안공관찰치료AOPP환자422례,이구복중독위주(97.16%),중、중도환자점87.44%.이규범치료전2년적병례작위대조,채용규범치료후,정점의원AOPP병사솔종9.87%강지1.66%,차이유통계학의의(χ2=27.92,P<0.01),명현저우동기해성보고종합구치수평(병사솔위8.92%),차이역유통계학의의(χ2=26.05,P<0.01).규범치료조아탁품평균용량위(37.54±17.76)mg,교전통치료조[(1280.70±69.22)mg]명현하강,차이유통계학의의(U=439.22,P<0.01),정맥빙급약우우정맥주사급약.규범치료조록해린정평균용량위(25.55±13.78)g,교전통치료조[(12.11±3.56)g]명현증가,차이유통계학의의(U=19.48,P<0.01).미견약물중독현상.결론 AOPP치료극수규범,특별재엄대농촌지구.차차건립적규범치료방안취득만의료효,가명현강저AOPP병사솔.
Objective To explore the norms of treatment of acute organophosphorus pesticide poisoning (AOPP), and observe the curative effect. Methods On basis of the pre-research, the norms of treatment of AOPP were summarized, and a multi-center clinical trial was performed in 6 hospitals selected from high incidence of AOPP in Shandong Province. Results 422 patients of AOPP in 6 hospitals in observation period were treated and observed by the norms of treatment. Among them, the proportion of oral poisoning was 97.16%, middle and severe degree were 87.44%. Compared with themselves 2 years ago before standard treatment, the curative effect of the norms of treatment for AOPP was much better than before. The mortality rate of AOPP declined from 9.87% to 1.66%(χ2=27.92, P<0.01), that was much better than the average therapeutic effect level of all our province in the same period (the mortality rate: 8.92%) (χ2=26.05, P<0.01). The average amount of atropine[(37.54±17.76)mg],dropped greatly[(1280.70±69.22)mg](U=439.22,P<0.01).The usage of atropine by continuous intravenous injection with venous pump was better than ordinary intravenous injection. The mean dosage of pralidoxime chloride increased twice than the previous (U=19.48,P<0.01). There was no drug poisoning. Conclusion The standard treatment of AOPP is urgently needed in our country, especially in rural area. By this trial, the satisfactory effect of the norms of treatment for AOPP summarized is observed and it reduces the fatality rate remarkably.