国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2010年
5期
574-576
,共3页
陈平%刘健%姚艺雄%蔡健梅%梁梅芳
陳平%劉健%姚藝雄%蔡健梅%樑梅芳
진평%류건%요예웅%채건매%량매방
总前列腺特异性抗原(t-PSA)%复合前列腺特异性抗原(c-PSA)%前列腺癌(PCa)%前列腺增生(BPH)
總前列腺特異性抗原(t-PSA)%複閤前列腺特異性抗原(c-PSA)%前列腺癌(PCa)%前列腺增生(BPH)
총전렬선특이성항원(t-PSA)%복합전렬선특이성항원(c-PSA)%전렬선암(PCa)%전렬선증생(BPH)
Total prostate-specific antigen(t-PSA)%Complexed prostate-specific antigen(c-PSA)%Prostatic neoplasms (PCa)%Benign prostatic hyperplasia(BPH)
目的 研究复合前列腺特异性抗原(c-PSA)、总前列腺特异性抗原(t-PSA)在鉴别诊断前列腺癌和良性前列腺增生时的应用价值.方法 选择两组实验对象,Pca组89例经B超、病理确诊的前列腺癌(Pca)者.BPH组为111例良性前列腺增生患者.采用化学发光法检测其c-PSA、t-PSA,记录结果并进行统计分析.结果 Pca和BPH组的c-PSA、t-PSA和年龄值,BPH和Pca组t-PSA含量(3.6±2.4)ng/ml、(15.2±16.2)ng/ml,差异有极显著性(P<0.01),年龄值两组间,差异无显著性(P>0.05).t-PSA的cutoff为10 ng/ml时,Pca89例中45例为假阴性(50.6%),t-PSA的cutoff为2.5 ng/ml时,Pca 89例中24例为假阴性(27.0%),但假阳性率相应升高.BPH和Pca的c-PSA含最(0.08±0.06)ng/ml、(28.9±37.6)ng/ml(P<0.01),c-PSA的cutoff为2.5 ng/ml时,Pca89例中18例为假阴性(20.2%).t-PSA的cutoff为10ng/ml时,与c-PSA同时阳性占46.1%,而将t-PSA的cutoff定为2.5 ng/ml时,与c-PSA同时阳性占69.7%.结论 c-PSA在t-PSA<10ng/mL的特异性优于t-PSA,t-PSA的cutoff为10 ng/ml的设置过高,建议将其调整为2.5ng/ml,结合c-PSA(cutoff:2.5 ng/ml)将有效提高Pca诊断的特异性和灵敏度.
目的 研究複閤前列腺特異性抗原(c-PSA)、總前列腺特異性抗原(t-PSA)在鑒彆診斷前列腺癌和良性前列腺增生時的應用價值.方法 選擇兩組實驗對象,Pca組89例經B超、病理確診的前列腺癌(Pca)者.BPH組為111例良性前列腺增生患者.採用化學髮光法檢測其c-PSA、t-PSA,記錄結果併進行統計分析.結果 Pca和BPH組的c-PSA、t-PSA和年齡值,BPH和Pca組t-PSA含量(3.6±2.4)ng/ml、(15.2±16.2)ng/ml,差異有極顯著性(P<0.01),年齡值兩組間,差異無顯著性(P>0.05).t-PSA的cutoff為10 ng/ml時,Pca89例中45例為假陰性(50.6%),t-PSA的cutoff為2.5 ng/ml時,Pca 89例中24例為假陰性(27.0%),但假暘性率相應升高.BPH和Pca的c-PSA含最(0.08±0.06)ng/ml、(28.9±37.6)ng/ml(P<0.01),c-PSA的cutoff為2.5 ng/ml時,Pca89例中18例為假陰性(20.2%).t-PSA的cutoff為10ng/ml時,與c-PSA同時暘性佔46.1%,而將t-PSA的cutoff定為2.5 ng/ml時,與c-PSA同時暘性佔69.7%.結論 c-PSA在t-PSA<10ng/mL的特異性優于t-PSA,t-PSA的cutoff為10 ng/ml的設置過高,建議將其調整為2.5ng/ml,結閤c-PSA(cutoff:2.5 ng/ml)將有效提高Pca診斷的特異性和靈敏度.
목적 연구복합전렬선특이성항원(c-PSA)、총전렬선특이성항원(t-PSA)재감별진단전렬선암화량성전렬선증생시적응용개치.방법 선택량조실험대상,Pca조89례경B초、병리학진적전렬선암(Pca)자.BPH조위111례량성전렬선증생환자.채용화학발광법검측기c-PSA、t-PSA,기록결과병진행통계분석.결과 Pca화BPH조적c-PSA、t-PSA화년령치,BPH화Pca조t-PSA함량(3.6±2.4)ng/ml、(15.2±16.2)ng/ml,차이유겁현저성(P<0.01),년령치량조간,차이무현저성(P>0.05).t-PSA적cutoff위10 ng/ml시,Pca89례중45례위가음성(50.6%),t-PSA적cutoff위2.5 ng/ml시,Pca 89례중24례위가음성(27.0%),단가양성솔상응승고.BPH화Pca적c-PSA함최(0.08±0.06)ng/ml、(28.9±37.6)ng/ml(P<0.01),c-PSA적cutoff위2.5 ng/ml시,Pca89례중18례위가음성(20.2%).t-PSA적cutoff위10ng/ml시,여c-PSA동시양성점46.1%,이장t-PSA적cutoff정위2.5 ng/ml시,여c-PSA동시양성점69.7%.결론 c-PSA재t-PSA<10ng/mL적특이성우우t-PSA,t-PSA적cutoff위10 ng/ml적설치과고,건의장기조정위2.5ng/ml,결합c-PSA(cutoff:2.5 ng/ml)장유효제고Pca진단적특이성화령민도.
Objective To research the using value of t-PSA and c-PSA to differential diagnosis the prostate neoplasms and BPH. Methods The level of t-PSA and c-PSA were measured in the 89 cases of PCa, 111 cases of BPH by Chemiluminescence analysis. Results The level of t-PSA was (3.6±2.4) ng/ml(BPH) and (15.2±16.2) ng/ml(PCa) (P<0.01). The false negative was 50.6% (cutoff= 10ng/ml) and 27.0% (cutoff =2.5ng/ml). The level of c-PSA was (0.08±0.06) ng/ml(BPH) and (28.9±37.6) ng/ml(PCa) (P<0.01), The false negative was 20.2% (cutoff =2.5ng/ml). When the cutoff of t-PSA was 2.5 ng/ml, to combine the c-PSA would raise the positive up to 69.7 %. Conclusion When the cutoff of t-PSA was 10.0 ng/ml, the c-PSA was significantly higher than t-PSA. We suggest adjust the cutoff of t-PSA to 2.5 ng/ml, and to combine the c-PSA would significant raise the Sensitivity and Specificity by diagnosis the prostate neoplasms.
